After meeting with U.K. Foreign Secretary David Cameron and German Foreign Minister Annalena Baerbock on Wednesday, Israeli Prime Minister Benjamin Netanyahu said he appreciates their advice, but added, "We will make our own decisions and the State of Israel will do everything necessary to defend itself."

Cameron told reporters after the meeting in Jerusalem, "It's clear the Israelis are making a decision to act."

"We hope they do so in a way that does as little to escalate this as possible, and in a way that -- as I said yesterday -- is smart as well as tough," Cameron added.

Cameron also reiterated that the "real need is to refocus back on Hamas, back on the hostages, back on getting the aid in, back on getting a pause in the conflict in Gaza."

"That's why I'm here today to talk to the Israeli government, to talk to the Palestinian Authority to try and push those things forward," Cameron said.

-ABC News’ Ellie Kaufman

The United States announced Tuesday it will impose new sanctions targeting Iran in the coming days following its "unprecedented air attack against Israel."

The sanctions include targeting Iran's missile and drone program and new sanctions against entities supporting the Islamic Revolutionary Guard Corps and Iran’s Defense Ministry, according to the White House's national security adviser, Jake Sullivan.

"We anticipate that our allies and partners will soon be following with their own sanctions,” Sullivan said in a statement. "We will not hesitate to continue to take action, in coordination with allies and partners around the world, and with Congress, to hold the Iranian government accountable for its malicious and destabilizing actions."

The U.S. is telegraphing its sanction plan in advance to underscore the large international response that the U.S. is coordinating and to signal to Iran there will be diplomatic costs to what they've done, a senior administration official told ABC News. The official said they believe this will have an impact, in part, by bringing other countries on board.

-ABC News' Selina Wang

Six months into the Israel-Hamas conflict, the conduct and ethics of some Israel Defense Forces members have increasingly come under the microscope.

Incidents ranging from pranks to potentially criminal acts are being exposed to the world, often by videos soldiers themselves have posted online, according to critics and Israeli officials.

In many pictures and videos that have circulated since the conflict began, and which were reposted by pro-Palestinian activists to millions of followers, IDF soldiers are seen blowing up buildings in Gaza while in combat, waving women’s underwear like flags and rifling through the possessions of Gazans with gleeful expressions.

Younis Tirawi, a Palestinian activist, says he’s seen thousands of videos of IDF soldiers reportedly behaving improperly.

"You can see all the soldiers liking their posts," Tirawi told ABC News.

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Secretary of State Antony Blinken spoke with Israeli war cabinet minister Benny Gantz, during which Blinken "continue[d] to send the same messages in all his conversations -- which is we do not want to see further escalation of the conflict," according to spokesperson Matt Miller.

Miller declined to say whether the U.S. assessed the threat of escalation had fallen, but an administration official said the amount of time that has already elapsed since Iran’s weekend attack had boosted hopes that Israel would exercise constraint.

Miller batted down reports that Iran and the U.S. were communicating through intermediaries in the wake of Tehran’s attack on Israel.

"There have not been such messages delivered. It's been days since we've communicated -- since we've sent messages to the government of Iran," Miller said. "And I say that as a reminder of something we've said before: Oftentimes, the Iranian government has misled the world about either messages they've passed to us or messages that we have passed to them."

-ABC News’ Shannon Crawford

The U.S. will try to help Israel intercept everything possible -- not just those that pass over U.S. ships -- despite Iran informing the U.S. that they should stay out of it, a senior U.S. official confirmed to ABC News.

In the coming hours the U.S. expects missile launches from Iran and southern Lebanon -- and maybe even the Houthis -- as well as drones, which take longer to reach target. The Iranians are trying to overwhelm the Israeli air defenses with drones and missiles coming in at different altitudes, speeds and directions -- but hitting targets at the same time, according to the official.

While the U.S. expects that most of these will be intercepted -- upwards of 85% -- the fear is that if any Israeli lives are lost, the Israeli response will be much bigger.

The target is believed to be three military bases, especially one where F-35s are kept. While these bases are relatively remote, there are towns nearby and these Iranian weapons are not completely accurate.

The U.S. has no doubt Israel will respond whether lives are lost or not. And that Iran itself will be targeted.

-ABC News' Martha Raddatz