Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes
The IDF says it struck military targets of terrorist organizations in Gaza.
Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.
The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.
Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.
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What to know about Iran's attack on Israel
Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.
Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.
Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."
Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.
No damage to Iran’s nuclear sites after Israeli strike: IAEA
Iran's nuclear sites have not been damaged by Israel's strike on Iran early Friday morning, according to the International Atomic Energy Agency (IAEA).
In a statement released on social media, IAEA chief Rafael Grossi says he "continues to call for extreme restraint from everybody and reiterates that nuclear facilities should never be a target in military conflicts."
Flight operations resume in Iran: State media
After suspending flights at several airports following reports of an explosion in Iran, Iranian state media said early Friday normal operations have resumed.
-ABC News' Will Gretsky
Flights to Tehran, Isfahan and Shiraz suspended after reports of explosion in Iran: Iranian state media
Flights to Tehran, Isfahan and Shiraz have been suspended following reports an explosion was heard in the city of Qahjavaristan, Iranian state media reported.
The city of Qahjavaristan is located near Isfahan Airport and the 8th Shekhari Base of the Army Air Force in the northwest of Isfahan.
-ABC News' Will Gretsky
Israeli missiles have hit a site in Iran
A U.S. official confirmed to ABC News Israeli missiles have hit a site in Iran. The official could not confirm whether Syria and Iraq sites were hit as well.
-ABC News' Martha Raddatz
What US officials expect in the coming hours
The U.S. will try to help Israel intercept everything possible -- not just those that pass over U.S. ships -- despite Iran informing the U.S. that they should stay out of it, a senior U.S. official confirmed to ABC News.
In the coming hours the U.S. expects missile launches from Iran and southern Lebanon -- and maybe even the Houthis -- as well as drones, which take longer to reach target. The Iranians are trying to overwhelm the Israeli air defenses with drones and missiles coming in at different altitudes, speeds and directions -- but hitting targets at the same time, according to the official.
While the U.S. expects that most of these will be intercepted -- upwards of 85% -- the fear is that if any Israeli lives are lost, the Israeli response will be much bigger.
The target is believed to be three military bases, especially one where F-35s are kept. While these bases are relatively remote, there are towns nearby and these Iranian weapons are not completely accurate.
The U.S. has no doubt Israel will respond whether lives are lost or not. And that Iran itself will be targeted.
-ABC News' Martha Raddatz