Israel-Gaza updates: 22, including 18 children, reported dead in Rafah strikes

The IDF says it struck military targets of terrorist organizations in Gaza.

Israel launched a retaliatory strike against Iran early Friday morning local time, a senior U.S. official told ABC News.

The strike followed Iran's attack on Saturday, when Tehran sent a volley of more than 300 drones and missiles toward targets in Israel, according to Israeli military officials. All but a few were intercepted by Israel and its allies, including the United States, officials said.

Iran's weekend attack came more than six months after Hamas terrorists invaded Israel on Oct. 7, after which the Israeli military began its bombardment of Gaza.


What to know about Iran's attack on Israel

Israeli officials said the country's Iron Dome defense system endured a big test from Iran's attack on Saturday, intercepting 99% of the 300 "threats of various types" thrown at it.

Iran's Islamic Revolutionary Guard Corps, according to Israel Defense Forces spokesperson Daniel Hagari, launched 170 unmanned aerial vehicles (UAVs), more than 120 ballistic missiles and more than 30 cruise missiles in the attack.

Hagari said "99% of the threats launched towards Israeli territory were intercepted -- a very significant strategic achievement."

Hagari said the attack resulted in only one known Israeli casualty, a 7-year-old girl who was severely injured when she was struck by shrapnel apparently from an intercepted missile.


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US Embassy in Jerusalem lifts shelter-in-place order

The U.S. Embassy in Jerusalem early on Sunday lifted its shelter-in-place order for US government employees after the threat from Iranian drones and missiles "diminished."

But the embassy warned that security in Israel "remains complex" and can change quickly.

"The U.S. Embassy in Jerusalem reminds U.S. citizens of the continued need for caution and increased personal security awareness as security incidents often take place without warning," the embassy said in a security alert.

-ABC News' Christopher Boccia and Kevin Shalvey


Blinken condemns attack

Secretary of State Antony Blinken condemned Iran's attack on Israel, saying the U.S. doesn't seek escalation but will support Israel's right to defend itself and will protect U.S. personnel in the Middle East.

"The United States condemns Iran's attack on Israel in the strongest terms," Blinken said in a statement.

He added that he'll be "consulting with allies and partners in the region and around the world in the hours and days ahead."

-ABC News' Shannon K. Crawford


US shot down about 70 Iranian drones in Israel, officials say

Two U.S. officials confirmed that U.S. forces shot down about 70 Iranian drones headed towards Israel.

One official added that one of the U.S. Navy destroyers in the eastern Mediterranean was also able to bring down an undetermined number of Iranian ballistic missiles.

One of the officials said the destroyer shot down three Iranian ballistic missiles.

-ABC News’ Luis Martinez


Shelter in place lifted in some areas of Israel

The Israel Defense Forces Aerial Defense Array successfully intercepted the majority of Iran's surface-to-surface missile launches using the "Arrow" Aerial Defense System, together with Israel's strategic allies, before the launches crossed into Israeli territory.

A small number of hits were identified, including at an IDF base in southern Israel, where minor damage was caused to infrastructure.

Over the past few hours, many dozens of hostile aircraft, as well as dozens of cruise missiles, from Iran were identified approaching Israeli territory and intercepted. Dozens of IAF fighter jets are currently operating to intercept all aerial threats approaching Israeli territory.

According to a situation analysis by IDF’s Home Front Command, the residents of the following towns: Northern Golan, Nevatim, Dimona, Eilat-City, Be'er Sheva and Arad no longer need to stay near a protected space.

The IDF said it is deployed on all fronts, prepared, and continuing to defend Israeli territory.

-ABC News' Will Gretsky


Wide concern in the White House that Iran's retaliatory attack will cause widespread war

Sources at the White House say there’s deep concern that an Iranian retaliatory strike against Israel -- and the possible Israeli response -- will widen this war.

President Joe Biden cut his weekend vacation short to consult with his national security team in preparation for this. They’ve been on high alert and knew this attack was imminent.

U.S. officials the military is prepared to provide assistance to defend Israel against attacks if needed.

The U.S. is already moving military assets to the region to deter Iran and help protect U.S. forces. Officials say they have been urging Iran against further escalation or attacks on U.S. forces. They’ve been stressing that the U.S. was not involved in the Damascus, Syria, strike earlier this month.

-ABC News' Selina Wang