Senate Majority Leader Chuck Schumer on Saturday spoke with top officials from the Central Intelligence Agency and the State Department during a briefing on the situation in Israel.

Schumer's office released a statement, stating, "The enormous loss of life is gut-wrenching, and I am appalled at the viciousness of the attack by Hamas on innocent Israeli civilians. I expressed my commitment to top Biden Administration officials – and directly to Ambassador Herzog – to do all I can to deliver everything Israel requires in this time of urgent need. I will continue to receive regular briefings."

Schumer is currently overseas in China on a Congressional trip.

The statement continued, "This is one of the worst attacks Israel has ever experienced, and friends of Israel in the US and around the world must stand strongly by her. My heart goes out to those that lost loved ones."

The Federal Aviation Administration issued a statement Saturday night urging U.S. airlines and pilots to "use caution" when flying in Israeli airspace.

In a Notice to Air Missions (NOTAM), the FAA said to exercise extreme caution at all altitudes due to the "ongoing conflict situation between Israel and Gaza."

NOTAM's statement told flight crews to remain in contact with "air traffic control at all times" and to monitor for "possible airspace closures."

A music festival near Re'im, Israel, came under fire amid the Hamas attacks, a festivalgoer recounted to ABC News.

Eliav Klein said that around 5:30 a.m. local time Saturday, missiles and gunfire began to target the festival. He and others ran "in a panic," losing track of many of their friends. Some of Klein's friends are still missing, he said.

Footage captured rockets flying across the horizon, interrupting the festival.

-ABC News' Christopher Looft

A senior White House official told reporters Saturday evening that it is "too early" to know what involvement, if any, Iran had in the attacks in Israel.

"It's too early to say whether the state of Iran was directly involved or planning, supporting," the senior administration official said. "We are going to be looking at that very closely."

"That said, there's no doubt Hamas is funded, equipped, armed by Iran and others," the official added.

Several Israeli officials, including President Isaac Herzog, have claimed that Iran helped coordinate the attacks.

The White House official said President Joe Biden and the administration have been in contact with Palestinian and Israeli officials throughout the day.

"We are in deep talks with the Israelis about some of their particular needs," the official said.

-ABC News' Fritz Farrow

As the Biden administration intensifies efforts to help American nationals leave Israel and Gaza, more than 20,000 U.S. citizens have reached out to the State Department asking for help in the wake of the Hamas attacks, including several hundred seeking to leave Gaza, according to two U.S. officials.

While not all have actively sought assistance with transportation, "many thousands" across Israel have indicated they needed help finding flights out of the country, the officials said.

Government-chartered planes have now started to ferry U.S. citizens from Israel to other countries in the region, though one official said the State Department still cannot share a detailed breakdown on the number of Americans whose departure it has already facilitated or the number of Americans still waiting for help "given this is an unfolding situation."

For Americans in Gaza, the U.S. is still eyeing the Rafah border crossing between Gaza and Egypt as a means of safe passage. Officials say they are very hopeful they will be able to work with Israel and Egypt to establish a corridor for U.S. citizens and other foreign nationals, but that it could take days to make substantial progress.

The Israeli government estimated that between 100 to 130 Americans were living in Gaza earlier this year. An official says the State Department believes hundreds more are visiting -- putting the total number in Gaza potentially between 500 and 600.

The State Department estimates that roughly 500,000 American citizens reside in Israel.

-ABC News' Shannon K. Crawford