Mahmoud Abbas, president of the State of Palestine, is pulling out of his Wednesday meeting with President Joe Biden.

"President Mahmoud Abbas decided to return to the homeland tonight, and he called for an emergency leadership meeting tonight," a senior adviser said Tuesday.

Biden is expected to leave the U.S. Tuesday night to head to Israel and Jordan.

-ABC News' Will Gretsky

At least 500 people have been killed in an explosion at Al Ahli Arab Hospital in the middle of Gaza, according to the Gaza Health Ministry.

The hospital served as a shelter for thousands of residents who fled their homes in northern Gaza.

The Israel Defense Forces denied responsibility for the explosion, saying a failed launch by the Palestinian Islamic Jihad caused the blast.

"From the analysis of the operational systems of the IDF, an enemy rocket barrage was carried out towards Israel, which passed in the vicinity of the hospital, when it was hit," IDF said.

The World Health Organization condemned the blast and called for "the immediate active protection of civilians and health care" workers.

This hospital "was one of 20 in the north of the Gaza Strip facing evacuation orders from the Israeli military," the WHO said in a statement. "The order for evacuation has been impossible to carry out given the current insecurity, critical condition of many patients, and lack of ambulances, staff, health system bed capacity, and alternative shelter for those displaced."

Palestinian Authority President Mahmoud Abbas has declared three days of mourning following the attack.

-ABC News' Will Gretsky

Israeli National Security Adviser Tzachi Hanegbi said Tuesday that officials plan to create "safe zones" in southern Gaza as the only places where residents can receive humanitarian aid.

The aid would be "on one condition," Hanegbi said in Hebrew. "If this aid does not reach civilians, but goes to murderers, [the safe zones] will simply not exist."

The Rafah border crossing between Egypt and Gaza has now endured four bombings from Israel, according to a spokesperson for Egypt's Ministry of Foreign Affairs.

The Rafah crossing was shut on Oct. 10 after it was hit by Israeli warplanes on the Palestinian side three times on Oct. 9 and 10.

"We are in constant contact with all U.N. agencies to extract a safe passage for the relief aid," Egyptian Foreign Minister Sameh Shoukry told BBC Radio. "There is not yet any sort of authorization for a safe passage from the other side of the crossing.”

Shoukry also called out Israeli leaders who urged Gaza residents to move south, saying, "Israel’s call for displacement to the South is in full contradiction to international humanitarian law, leaving people with no water, electricity or food."

National Security Council spokesperson John Kirby avoided saying if the U.S. believed Israel's calls for civilians in Gaza to evacuate in the next 24 hours was possible but acknowledge that it was a "tall order" given how densely populated the area is.

"Well, I think we're going to be careful not to get into armchair quarterbacking the tactics on the ground by the IDF. What I can tell you is we understand what they're trying to do. They're trying to move civilians out of harm's way and giving them fair warning. Now, it's a tall order. It's a million people, and it's a very urban, dense environment, already a combat zone. I don't think anybody's underestimating the challenge here of affecting that evacuation," Kirby said in an interview on CNN Friday morning.

"But it's pretty clear that what they're trying to do is to the maximum extent possible avoid civilian casualties and also separate Hamas from the human shields. I mean, Hamas actually gave a counterorder telling Palestinians in Gaza to stay at home. Why? Because having human shields, they think, protects them," Kirby continued.

Asked about their efforts to secure a safe passage for civilians out of Gaza, Kirby reiterated that the U.S. is talking to Israel and Egypt but would not comment further on progress.

On the Rafah crossing specifically, Kirby said "So far it's still closed. But that doesn't mean were not going to still try as hard as we can to talk to the Israelis and Egyptians about getting it open and having some sort of safe passage out. It's important that we also continue to work to make sure that humanitarian assistance can get in. The United States has no intention of stopping our efforts to continue to deliver humanitarian assistance, but there has to be a path in, there has to be a path out."

Kirby had no update on the Americans who are believed to be held hostage in Gaza and could not confirm reports that 13 hostages have been killed by Israeli airstrikes, as Hamas has claimed.

-ABC News' Molly Nagle