As Israel's offensive on Rafah intensifies, the United Nations Relief and Works Agency for Palestine Refugees estimates that around 110,000 people have now fled Rafah looking for safety.

"The only hope is an immediate Ceasefire," the UNRWA said in a statement Friday.

-ABC News' Will Gretsky

Cease-fire negotiations between Hamas and Israel are on pause, with no negotiations currently happening, according to an Israeli source familiar with the talks.

-ABC News' Jordana Miller

UNICEF officials continued to raise an alarm over the humanitarian conditions in Gaza, saying people are "exhausted, terrified" and don't have access to proper sanitation facilities and warn that if aid is not allowed into Gaza in the next 48 hours conditions will deteriorate further.

"I have been working on large-scale humanitarian emergencies for the best part of the last 30 years and I've never been involved in a situation as devastating, complex or erratic as this," James Elder a spokesperson for UNICEF, said.

"When I arrived in Gaza in the middle of November, I was shocked by the severity of the impact of this conflict on children and, impossibly, it has continued to worsen since. Yesterday, I walked around Al-Mawasi, the so-called 'humanitarian zone’ that people in eastern Rafah are being told to move to. More than 100,000 people have fled Rafah in the last 5 days and the stream of displacement continues. The roads to Mawasi are jammed – many hundreds of trucks, buses, cars and donkey carts loaded with people and possessions," Elder said.

Food stock for people in the south is expected to run out on Saturday while lack of fuel means that hospital wards cannot function. Elder also warned that a ground offensive in Rafah will lead to the number of children dead increasing "dramatically," with 14,000 being killed already.

"For 5 days, no fuel and virtually no humanitarian aid entered the Gaza Strip and we are scraping the bottom of the barrel. This is already a huge issue for the population and for all humanitarian actors but in a matter of days, if not corrected, the lack of fuel could grind humanitarian operations to a halt," Elder said.

"At a time when people are being forced to pick up and move again, the lifesaving supplies that sustain and support them have been entirely cut off. Let’s be very clear – this will result in children dying. Deaths that can be prevented," Elder said.

-ABC News' Will Gretsky

Prime Minister Benjamin Netanyahu made it clear in a 46-minute interview with McGraw that Israel plans to proceed with its operation in Rafah.

McGraw interviewed Netanyahu from Jerusalem with a sweeping view of the city in the background on a streaming platform called Merit+.

Netanyahu said Israel has destroyed "20 battalions of Hamas' 24 terrorist battalions," and the final four are in Rafah.

"We’ve achieved, we’ve destroyed about 20 battalions of Hamas' 24 terrorist battalions, we have another four ... they're in Rafah, and that’s why we want to go into Rafah because we can’t leave them there," Netanyahu told McGraw.

Netanyahu also criticized students protesting on college campuses, saying their understanding of history goes "back to breakfast, at best."

"What is happening on American campuses and American cities, you got ... first of all, you have a lot of ignorant people there," Netanyahu said. "I'm sorry to say, whose sense of history at best goes back to breakfast. Not even that, OK? They don't have the faintest clue what Hamas is."

Netanyahu pointed to what he said were dangerous comments from American college presidents.

"When the president of the university is asked, well, what would you say if somebody calls for the genocide of Jews? And [they] say it depends on the context. No, it doesn't. No, it doesn't."

ABC News' Ellie Kaufman and Hajah Bah

Although the Biden administration said it expected the Kerem Shalom and Rafah gates to be at least partially opened for humanitarian aid by Wednesday, the State Department was much less optimistic. However, the U.S. vowed it would continue to press Israel to get both portals up and running again.

While Kerem Shalom reopened Wednesday, aid had not been allowed to pass through because of "logistical and security concerns on the ground," State Department spokesperson Matt Miller said during a briefing Wednesday. He also said fuel had not been able to enter Gaza through Rafah.

"We think it's critical that Rafah be open for fuel because without fuel deliveries into Rafah, humanitarian assistance that comes in through Kerem Shalom can't actually be delivered. The two are critically linked," Miller said. "We're continuing to push for that to happen."

Miller didn’t provide any updated timeline on when the U.S. expected the crossings would be functional again, but said it was imperative that Israel act to increase the amount of aid allowed into Gaza following what he described as a "fairly dramatic dip" this week.

"When it comes to the level of humanitarian assistance, the results as they are today are just unacceptable. There's no other way to put it," Miller lamented.

He continued, "We are making quite clear to the government of Israel that we need to see those decreases reversed. We need to get back to where we were, and we need to see the levels continue to increase and see those sustained, and that is why we need to see Kerem Shalom and Rafah opened."

-ABC News' Shannon Crawford