Prime Minister Benjamin Netanyahu made it clear in a 46-minute interview with McGraw that Israel plans to proceed with its operation in Rafah.

McGraw interviewed Netanyahu from Jerusalem with a sweeping view of the city in the background on a streaming platform called Merit+.

Netanyahu said Israel has destroyed "20 battalions of Hamas' 24 terrorist battalions," and the final four are in Rafah.

"We’ve achieved, we’ve destroyed about 20 battalions of Hamas' 24 terrorist battalions, we have another four ... they're in Rafah, and that’s why we want to go into Rafah because we can’t leave them there," Netanyahu told McGraw.

Netanyahu also criticized students protesting on college campuses, saying their understanding of history goes "back to breakfast, at best."

"What is happening on American campuses and American cities, you got ... first of all, you have a lot of ignorant people there," Netanyahu said. "I'm sorry to say, whose sense of history at best goes back to breakfast. Not even that, OK? They don't have the faintest clue what Hamas is."

Netanyahu pointed to what he said were dangerous comments from American college presidents.

"When the president of the university is asked, well, what would you say if somebody calls for the genocide of Jews? And [they] say it depends on the context. No, it doesn't. No, it doesn't."

ABC News' Ellie Kaufman and Hajah Bah

Amid reports that cease-fire negotiations between Hamas and Israel have fallen through, the U.S. State Department is saying hope still remains for a deal. The State Department also refuted the notion that President Joe Biden's decision to halt some arms transfers to Israel — and his assertion that he will cut off additional shipments if the country invades Rafah — had weakened its position at the negotiating table.

"That is not at all our assessment of the hostage talks. We actually think that a Rafah operation would weaken Israel’s position both in these talks and writ large," State Department spokesperson Matt Miller said, arguing a major incursion would "further weaken Israel’s standing in the world."

Although the paused arm shipments won’t impact Israel’s readiness to conduct a major operation in Rafah, some U.S. officials who have long been skeptical that Hamas will ever agree to a deal that involves handing over all of the hostages say the group could interpret the move (and Biden’s public warning) as a compelling sign that support for Israel among its closest allies is beginning to crumble.

Despite the heightened tensions between the Biden administration and Benjamin Netanyahu’s government, Miller said the U.S. would continue to work with Israel in the hopes of reaching a deal.

"We continue to engage with the Israeli government on the amendments to the proposal that Hamas submitted earlier this week,” Miller said. “We continue to work to try to finalize the text, try to get an agreement. And I will just say that any effort like this is incredibly difficult. This one has certainly been incredibly difficult, but we will continue to stay engaged because we believe it's in the interest of all parties."

-ABC News' Shannon Crawford

Amid tensions between the U.S. and Israel over the invasion of Rafah, Israeli Prime Minister Benjamin Netanyahu said Israel will stand alone if it has to.

"Today we are much stronger. We are determined, and we are united to defeat our enemy and those who seek our souls. If we have to stand alone, we will stand alone," Netanyahu said in a statement Thursday.

"I already said that if we have to - we will fight tooth and nail," Netanyahu said.

Following threats from President Joe Biden to cut off arms to Israel if it launches a full-scale invasion of Rafah, the Israel Defense Forces say they have the armaments they need for operations in Rafah.

"The IDF has armaments for the missions it plans, and we also have what we need for the missions in Rafah. I say this in the context of everything that has come up with the United States and it is important to say it," Daniel Hagari, a spokesperson for the IDF, said Thursday.

"The United States has provided security assistance to the State of Israel and the IDF so far in an unprecedented way during the war, what is no less important than this is the military assistance and cooperation of the American Central Command and the IDF," Hagari said.

A new report from the United States Departments of State and Defense said that given "Israel's significant reliance on U.S.-made defense articles" it is "reasonable to assess" that some have been used in instances "inconsistent" with Israel's obligation under international law.

The assessment, which came as part of a report ordered by President Joe Biden, examined the use of U.S.-supplied arms in active conflict zones, and also said that the U.S. could not compile enough evidence to prove that the country used American defense articles in violation of international humanitarian law.

"We do not have complete information to verify whether US defense articles covered under NSM-20 were specifically used in actions that have been alleged as violations of IHL (international humanitarian law) or international human rights law during the period of the report," the document says. "The nature of the conflict in Gaza makes it difficult to address or reach conclusive findings on individual incidents."

While the report said the Israeli government has "the knowledge, experience, and tools" to implement "best practices for mitigating civilian harm," the high number of civilian casualties "raise substantial questions about whether the IDF is using them effectively in all cases."

Additionally, the report noted that Israel did not cooperate with U.S. efforts to ramp up humanitarian aid and distribution in Gaza during the initial months of the conflict, but that officials have observed improvements.

-ABC News' Shannon Crawford and Anne Flaherty