A series of Israeli airstrikes across Gaza over the weekend and into Monday morning pushed the total death toll in the strip since Oct. 7, 2023, to more than 45,000 people, according to data from the Health Ministry in the Hamas-run territory.

Per ministry figures, more than 2% of Gaza's total pre-war residents of 2.23 million people have been killed in 14 months of conflict with Israel.

-ABC News' Joe Simonetti

Israeli Prime Minister Benjamin Netanyahu said Sunday that his nation has no interest in conflict with the incoming Syrian government, though indicated that Israeli airstrikes and occupation of Syrian territory will continue.

"We have no interest in a conflict with Syria," Netanyahu said in a statement. "We will determine Israeli policy regarding Syria according to the reality on the ground."

"I recall that for decades Syria was an active enemy state toward Israel," he said. "It has attacked us repeatedly."

Speaking of former President Bashar Assad's close ties with Iran and its proxies, Netanyahu continued, "It allowed others to attack us from its territory. It allowed Iran to arm Hezbollah through its territory."

The prime minister issued the statement after another night of heavy airstrikes across Syria. The Syrian Observatory for Human Rights said Monday there have been around 473 Israeli airstrikes on the country since Assad's fall on Dec. 8.

"Over the course of several days, we have destroyed the capabilities that the Assad regime took decades to build," Netanyahu said. "We have also struck the weapons supply routes through Syria to Hezbollah."

Netanyahu said he and Defense Minister Israel Katz had instructed the Israel Defense Forces "to thwart the potential threats from Syria and prevent terrorist elements from taking control close to our border," a reference to Israeli occupation of a buffer zone between the two nations established in a 1974 peace deal.

"We are committed to preventing the rearming of Hezbollah," Netanyahu said. "This is a prolonged test for Israel, which we must meet, and which we will meet. I unequivocally declare to Hezbollah and to Iran: In order to prevent you from attacking us, we will continue to take action against you as necessary, in every arena and at all times."

Over the weekend, Netanyahu's government also approved a plan to double the territory of the Golan Heights, which has been occupied by Israel since 1967 but is still recognized as Syrian territory by the vast majority of the international community.

"We will continue to hold onto it, cause it to blossom and settle in it," Netanyahu said.

Israel unilaterally annexed the strategic area -- which overlooks Damascus from the southwest -- in 1981. The U.S. recognized Israeli sovereignty over the region in 2019.

-ABC News' Joe Simonetti

The U.S. Embassy in Damascus -- which suspended operations in 2012 -- said in a Monday post to X that the "security situation in Syria continues to be volatile and unpredictable with armed conflict and terrorism throughout the country."

U.S. citizens, it said, "should depart Syria if possible. U.S. citizens who are unable to depart should prepare contingency plans for emergency situations and be prepared to shelter in place for extended periods."

U.S. officials have said they are in touch with the most prominent rebel groups now building a transition government after toppling former president Bashar Assad's regime, but the eventual shape of U.S.-Syrian relations remains unclear.

Hayat Tahrir al-Sham -- the most prominent of the rebel groupings -- has roots in al-Qaeda and is still listed as a terrorist organization in the U.S. and European Union. Its leader, Ahmed al-Sharaa, better known by his nom de guerre Abu Mohammed al-Jolani, is still the subject of a $10 million U.S. bounty.

The U.S. government "is unable to provide any routine or emergency consular services to U.S. citizens in Syria," the embassy said. "U.S. citizens in Syria who are in need of emergency assistance to depart should contact the U.S. Embassy in the country they plan to enter."

The embassy urged citizens in Syria to be "prepared to shelter in place should the situation deteriorate" and to ensure access to all required travel documents.

Prime Minister Benjamin Netanyahu on Sunday night released a video in Hebrew addressing Israel's actions in Syria. He says he discussed this with President-Elect Trump "last night." He called it a "very friendly, very warm and very important conversation," and said they spoke about "the need to complete Israel's victory," as well as freeing the hostages in Gaza.

On Syria, Netanyahu said he has instructed the Israel Defense Forces "to thwart potential threats from Syria, and to prevent terrorist elements from taking over near our border." He also said the IDF's airstrikes in Syria have destroyed "capabilities that the Assad regime had built over decades," as well as the "arms supply routes from Syria to Hezbollah."

Netanyahu said Israel has "no interest in confronting Syria" but also said Israel will continue to act to stop Hezbollah from rearming "as much as necessary, in every arena and at any time."

-ABC News' Bruno Nota