Joe Biden 1st Sitting President or Veep to Lose Child in Over 50 Years

John F. Kennedy's son Patrick died two days after his birth.

— -- Rarely has a sitting president or vice president lost a child.

"It is with broken hearts that Hallie, Hunter, Ashley, Jill and I announce the passing of our husband, brother and son, Beau, after he battled brain cancer with the same integrity, courage and strength he demonstrated every day of his life,” the vice president said in a statement.

Here are some presidents who lost a child while in office:

Abraham Lincoln:

In 1862, President Lincoln's son, 11-year-old Willie, died from typhoid fever. The boy may have contracted the disease from contaminated water at the White House, according to the Washington Post.

In 1924, President Coolidge's son, Calvin Jr., died from blood poisoning. The teenager was likely poisoned from a blister he got on his toe while playing lawn tennis on the White House South Grounds.

John F. Kennedy:

Kennedy was assassinated in Texas just months later.