Biden's nominee for surgeon general, Dr. Vivek Murthy, who served in the same role in Obama administration, reminded in his remarks that COVID-19 is not the only health crisis devastating families and shortening life spans in America while warning that even with the best policies, the nation must overcome the fear and distrust that many are feeling amid the pandemic.

"In my new expanded role, I will work to bring a health focus to our policies across government so that our schools, our workplaces and our communities can be forces for strengthening our health and wellbeing, but the truth is that the very best policies, and even the best vaccines and treatments, will not heal our nation unless we also overcome the fear, anxiety, anger and distrust that so many Americans are feeling right now," Murthy said.

"So more than anything, I will come to this role as a doctor, one who learned the most important lessons about medicine not in medical school, but from the clinic that my parents opened when they first came to America as immigrants decades ago," he added.

Drawing from personal experience, Murthy went on to say he is "endlessly grateful to serve one of the few countries in the world where the grandson of a poor farmer in India could be asked by the president-elect to look out for the health of an entire nation."

California Attorney General Xavier Becerra, Biden's nominee to lead the Health and Human Services Department who would be the first Latino in the position if confirmed, said the incoming Biden administration will elevate the knowledge of medial professionals and build a country where health care is a right, not a privilege.

"At HHS, tackling pandemics, saving lives, keeping us healthy, should be our calling card. And we won't forget that there is a second "H" in HHS, the human services: the work we do for our children, the seniors and and disabled. They will stand tall in a Biden-Harris HHS," Becerra said.

Becerra also shared a personal story, of his father passing away peacefully at home on New Year's Day, contrasting it to the present moment.

"No one should ever have to die alone in a hospital bed, loved ones forced to stay away. That seems so contrary to the values of a great nation, the values that drew my parents like generations before and after them to come to America," he said.

Becerra led the states' defense of the Affordable Care Act after the Trump administration sued to dismantle the program earlier this year.

Ahead of introducing his health care picks, Biden made his mask campaign official and called on all Americans to wear a mask for the first 100 days of his presidency as part of three key objectives he's asking his health care team to complete in his first 100 days in office.

"My first 100 days won’t end the COVID-19 virus. I can't promise that," Biden said. "We didn’t get into this mess quickly. We're not going to get out of it quickly. It's going to take some time. But I'm absolutely convinced that in 100 days we can change the course of the disease and change life in America for the better."

Biden said his team's second initiative is to have "at least 100 million COVID vaccine shots into the arms of the American people in the first 100 days." The initiative comes as the Biden team has said it's seen "no detailed plan" on vaccine distribution from the Trump administration.

Finally, Biden said getting children back to school and keeping them in school will be a "national priority" for the team in the first 100 days, saying Congress can help make this happen with the appropriate funding.

"I'm encouraged by the bipartisan efforts in Congress around a $900 billion economic relief package which I've said is critical, but this package is only a start for more action early next year," Biden added.

Biden is introducing a slate of health care experts and officials who will lead his administration's response to the ongoing COVID-19 crisis.

"Today, I’m very proud to be announcing our health care and COVID team at a critical time, as we near the end of one of the toughest years we've faced as a nation," Biden said, adding this group of "world class experts" will be "ready on day one."

California attorney general and former California congressman, Xavier Becerra, is Biden's nominee for secretary of Health and Human Services. If confirmed, he would be the first Latino to lead the department.

Vivek Muthy has been nominated to be U.S. surgeon general, a role he served in during the Obama administration.

Dr. Rochelle Walensky, a leading expert on virus testing, prevention and treatment, is nominated to serve as director of the Centers for Disease Control and Prevention.

Dr. Marcella Nunez-Smith, one of the country’s foremost experts on health care disparities, will serve as the COVID-19 equity task force chair.

As Biden said last week, Dr. Anthony Fauci will stay on in his current role as as director of the National Institute of Allergy and Infectious Diseases and will take on the elevated role of Biden's chief medical adviser on the COVID-19 pandemic.

Jeff Zients will serve as coordinator of the COVID-19 response and counselor to the president, and Natalie Quillian will serve as deputy coordinator of the COVID-19 response.

Biden has arrived at The Queen Theater in Wilmington, Delaware, his de facto transition headquarters ahead of his inauguration in 44 days again without a medical accessory he's donned for the larger part of the last week.

Although Biden's doctor said last Sunday he would likely be wearing a walking boot for "several weeks" after he sustained hairline fractures in his right foot, Biden was not wearing the boot when he walked into the theater Monday afternoon. While attending a Saturday Mass in Wilmington, he was also spotted without what Biden has referred to as "the big boot."

Biden has said his foot feels “good” despite sustaining the fractures just over a week ago, and addressed the boot issue during an interview with CNN Thursday, noting that the larger cast is a little clumsy and while he wears it "most of the time," he’s been given a smaller option for going out in public.

Biden will receive the President’s Daily Brief and meet with transition advisers on Monday, according to his public schedule, and pre-tape transition production elements at The Queen, his team said.

It comes ahead of Biden introducing his top health care picks to the public on Tuesday including California Attorney General Xavier Berecca to lead the Health and Human Services Department and Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, as Biden's chief medical adviser to lead the country through the worsening COVID-19 pandemic.

-ABC News' Molly Nagle