Biden travels from Wilmington, Delaware, where he spent the night, to the White House Monday morning. In the afternoon, the president meets virtually with Mexican President Andrés Manuel López Obrador.

Biden will broach a variety of topics in his discussion with López Obrador including managing increasing migration flows, combating cross-border narcotics trafficking and addressing the ongoing health crisis, according to a senior administration official. This will be a follow up to the conversation between the two leaders on Jan. 22.

Included in the discussion of migration flow will likely be the reluctance in the Mexican state of Tamaulipas to accept families with young children. An administration official confirmed to ABC News that Mexican officials had rejected families with children under the age of 6, and as a result, they were then released into the interior of the U.S. The official described it as "creating a challenge" for the U.S. in managing migration flows.

The senior official underscored that the Trump-era protocols used to expel nearly everyone attempting to cross the border, known as Title 42, are a temporary measures employed while immigration authorities work to build capacity for migrant processing in the U.S.

Broadly, the two leaders are expected to discuss avenues for continued cooperation and partnership on security, trade and migration.

The White House COVID-19 response team holds a briefing at 11 a.m. and White House press secretary Jen Psaki holds a briefing at 12 p.m.

-ABC News' Quinn Owen