The president briefly turned to an initiative he has already failed to pass: a $15 minimum wage.

After much back-and-forth on Capitol Hill, the Senate parliamentarian ultimately ruled this provision could not be passed under budget reconciliation rules, and was dropped from the $1.9 trillion COVID-19 relief package.

Biden, apparently, thinks the fight isn't over... despite the fact he will never get 10 Republicans to join Democrats in the Senate to pass it.

"And by the way, while you’re thinking about sending things to my desk, [chuckles] let's raise the minimum wage to $15," Biden said. "No one, no one working 40 hours a week, no one working 40 hours a week should live below the poverty line."

Once again nodding to the historic pair of women behind him, Biden called on Congress to pass the Equal Pay Act.

"We need to ensure greater equity and opportunity for women. And while we're doing this, let's get the Paycheck Fairness Act to my desk as well. Equal pay. It's been much too long.
And if you wonder whether it’s too long, look behind you," Biden added.

-ABC News' Sarah Kolinovsky

Biden asked Vice President Kamala Harris to take the lead on his infrastructure, saying that if she does he knows, "it will get done."

Harris, who already has the monumental task of addressing the root causes of migration on her plate, nodded in the background.

Biden cast his infrastructure bill as a jobs plan, calling it the biggest jobs plan since World War II.

"Look, think about it. There is simply no reason why the blades for wind turbines can't be built in Pittsburgh instead of Beijing. No reason, none. No reason," Biden said in another strong line that elicited loud cheers.

-ABC News' Sarah Kolinovsky

Biden grew emotional as he discussed research to fight diseases like Alzheimer's, diabetes and cancer. He talked about his moonshot proposal and mentioned his son Beau, who lost his battle to brain cancer in 2015.

"I know of nothing that is more bipartisan, so let's end cancer as we know it," Biden said. "It is within our power. It's within our power to do it."

Biden called on Congress to pass Protect the Right to Organize Act "so we can support the right to unionize."

"Wall Street didn't build this country. The middle class built the country—and unions built the middle class!"

Biden is correct that his administration has made great strides in the vaccine rollout, but the credit isn’t entirely his. While his numbers are accurate, they miss critical context.

“When I was sworn in on Jan. 20, less than 1% of the seniors in America were fully vaccinated against COVID-19,” he said. “One hundred days later, 70% of seniors in America over 65 are protected.”

When Biden took office on Jan. 20, only two vaccines -- Pfizer and Moderna -- had been authorized for a little more than a month. Supply was low early on, but always expected to ramp up through spring.

The Trump administration had initiated government contracts with the vaccine makers, and tapped the military to help oversee distribution. Trump aides also set up the program for some 40,000 pharmacies to deliver the vaccinations -- a program Biden referenced in his speech.

Biden has since relied on those Trump-era contracts and pharmacy program to expand vaccinations to Americans.

Where Biden can take credit: Expanding government contracts with vaccine makers to buy more doses. He also set up federally run mass vaccination sites, as well as mobile clinics, with a focus on hard-hit areas. And he’s partnered with community centers to help deliver the vaccine in disadvantaged communities.

-ABC News' Anne Flaherty