Biden responded to concerns that another shutdown could harm the economy, already hurting from closures caused by the pandemic.

"I'm going to shut down the virus, not the country," he said. "It's his ineptitude that caused the virus -- caused the country to have to shut down in large part. Why businesses have gone under, why schools are closed, why so many people have lost their living and why they're concerned."

After attacking Trump for golfing during the pandemic, Biden said he hadn't ruled out additional shutdowns if necessary.

"You need standards," he said. "The standard is if you have a reproduction rate in a community that's above a certain level, everybody says slow up. More social distancing. Do not open bars and do not open gymnasiums."

In rebuttal, Trump criticized Democratic governors in several states for shutting down in response to the pandemic.

"They're shut down so tight and they're dying," he said. "They're dying. And he supports all these people. All he talks about is shutdowns. No, we're not going to shut down. And we have to open our schools."

In an example of how young people have better outcomes with coronavirus, the president mentioned his son Baron who tested positive.

"By the time I spoke to the doctor the second time, he was fine. It just went away. Young people -- I guess it's their immune system," he said.

Trump and Biden have contradictory views on the president's handling of the pandemic with Trump asserting he's done better than any other world leader and Biden claiming he's done "virtually nothing."

Trump's insisted again that the pandemic is "going away," touting his administration's efforts on therapeutics and vaccines.

"I don't think we're gonna have a dark winter at all," Trump said. "I say we're learning to live with it. We have no choice. We can't lock ourselves up in a basement like Joe does," drawing a laugh from Biden.

Biden emphasized the lives already lost, making a direct appeal to those at home.

"Number one, he says that we're, you know, we're learning to live with it. People are learning to die with it," Biden said. "You folks home who have an empty chair at the kitchen table this morning, that man or wife going to bed tonight and reaching over to try to touch their -- out of habit where their wife or husband was is gone. Learning to live with it? Come on."

When Trump threatened that Biden would shutdown the country if elected, causing massive economic depression, Biden said, "I'm going to shut down the virus, not the country."

In response to a question on how he would lead the country out of the crisis caused by the COVID-19 pandemic, Biden cited the more than 220,000 Americans who had died from the virus.

"Anyone who's responsible for that many deaths should not remain as president of the United States of America," he said.

Biden went on to say that Trump doesn't have a plan for dealing with the virus. He called for mask wearing, and a national policy on mask wearing, more testing and a national policy on reopening schools and businesses.

"I will take care of this. I will end this," Biden said to close out his first answer. "I will make sure we have a plan."

Trump tackled the first question on the coronavirus pandemic but stuck to his stance the pandemic is "rounding the corner" and "going away."

"Since the two of you last shared a stage, 16,000 Americans have died from COVID," Welker said. "So please be specific, how would you lead the country during this next stage of the coronavirus crisis?"

"As you know, 2.2 million people modelled out were expected to die," Trump began. "We closed up the greatest economy in the world in order to fight this horrible disease that came from China."

He went on to draw from his personal experience contracting COVID-19, downplaying its side effects and touting the country's therapeutics.

"I can tell you from personal experience that I was in the hospital. I had it. And I got better," Trump said. "And I will tell you that I had something that they gave me, a therapeutic, I guess they would call it, some people could say it was a cure. But I was in for a short period of time and I got better very fast or I wouldn't be here tonight. And now they say I'm immune. Whether it's four months or a lifetime, nobody has been able to say that, but I'm immune."

"It will go away and as I say, we're rounding the turn. We're rounding the corner. It's going away," he added.

TRUMP'S CLAIM: "We have a vaccine that's coming. It's ready. It's going to be announced within weeks. And it's going to be delivered." ... "Johnson & Johnson is doing very well. Moderna is doing very well. Pfizer is doing very well. And we have numerous others."

FACT CHECK: A COVID-19 vaccine isn't ready right now. But it is true that two companies -- Pfizer and Moderna -- could seek emergency use authorization in November or December.

Like Pfizer and Moderna, Johnson & Johnson's vaccine is also in late-stage studies, but Johnson & Johnson paused its trial earlier this month to investigate an unexplained illness.

As the chief adviser to the government vaccine distribution initiative Operation Warp Speed, Dr. Moncef Slaoui told ABC’s Bob Woodruff this week that if a vaccine is authorized before the end of the year approximately 20 million to 40 million doses of it will be stockpiled and ready for distribution for a limited population. At first, only high priority Americans, like those over 65, will have access, but by the springtime more Americans should have access.

Slaoui said that vaccine trials are going as fast as it’s safe to go, pledging to resign if he felt undue pressure from the White House. Slaoui said that by June 2021, it's possible "everybody" in the United States could have been immunized.

-ABC News' Sony Salzman and Sasha Pezenik