A government shutdown would be detrimental to the State Department's efforts on the world stage, Secretary of State Antony Blinken said at a news conference Friday afternoon.

"Our work would clearly be affected by this. It would make it harder to do everything we do to try to advance national security. So, we urge Congress not to take this step," Blinken said.

Asked if he would view a continuing resolution that didn't include supplemental funding for Ukraine as a suitable compromise, he didn't answer.

"I'm not going to comment on the specifics of legislative arrangements. That is up to the members of Congress," he said.

--ABC News' Shannon Crawford

A partial government shutdown would hurt military recruitment -- as well as its members, White House National Security Council spokesman John Kirby said Friday.

Military recruitment, which is already suffering, would take a hit in a shutdown and send a "horrible message to young people" and deter them from enlisting, Kirby said.

"Young people … graduating high school here, you know, in the spring, they can be forgiven for thinking, 'Maybe that's not where I want to go. Why would I want to sign up and do that dangerous work, when I can't even guarantee that there's going to be a paycheck for it?'" Kirby said.

While Kirby said there is patriotism and a sense of duty in serving in the military, he said a shutdown hurt service members.

"You start missing a couple of paychecks when you're in active-duty service to the nation, and it starts to hurt. You can't buy groceries, or as many, anyway. Bills are tougher to pay, rent and mortgage payments are tough to cover."

If the government shuts down, an estimated 3.5 million federal workers would have to go without pay – about 2 million of which are in the military.

ABC News' Ben Gittleson

Unlike shutdowns past, where lawmakers passed appropriations bills to fund the Department of Defense personnel, the White House estimates that 2 million military members will have to without pay if the government shuts down over the weekend.

President Joe Biden, at a farewell ceremony for Gen. Mark Milley, said if the House fails to keep the government open it will have "failed all of our troops," going as far as calling it a "disgrace."

Austin Carrigg, a military spouse, spoke to ABC News Live about the impact a partial government shutdown will have on her family. Carrigg said she and her husband, Master Sgt. Joshua Carrigg will be in a life-or-death situation if they don't receive a paycheck because they might not be able to afford medication for their 11-year-old daughter, who has Down syndrome, a congenital heart defect, metabolic disorder and recently suffered a catastrophic stroke.

"It really feels like a smack in the face that they think so little of us that they're unwilling to pay our troops while they are going through this negotiation," Carrigg explained about her frustrations with lawmakers. "We understand that negotiations have to happen and that everybody takes a stand. But that stance shouldn't be on the backs of our military families and that's what they're doing this time."

OMB Director Shalanda Young told ABC News Senior White House Correspondent Selina Wang that to avert a shutdown, "we're doing everything we can to plead, beg, shame, House Republicans: do the right thing."

Asked to respond to the concerns of mothers who rely on WIC for their babies' nutrition, Young gave an impassioned response:

"The cavalierness is what gets me. I've heard people say in a Republican House conference, 'Oh, shutdown. It's not that bad. It's not like the debt ceiling.' Well, you go tell people who cannot pay their daycare bill ... You go tell men and women in uniform that they don't get a paycheck when they show up to work every day. You will tell that mother that she cannot … And you're right, it -- it sets an expectation for how people deal with their government throughout their lives."