White House press secretary Jen Psaki was asked during a press briefing Wednesday whether the postponement of Senate hearings for Biden's pick to manage the Office of Management and Budget was a setback and Psaki said she wouldn't "put it in those terms."

Psaki emphasized that the administration is still "fighting" for Tanden's nomination and remains committed to getting Biden's pick confirmed. When asked whether Tanden had offered to withdraw her nomination, Psaki said that is "not the stage" the administration is in.

"The stage we’re in is working to continue to fight for her nomination. And, as you know, it’s a numbers game, right? It's a matter of getting one Republican to support her nomination," Psaki said. "We're continuing to do that outreach, answer questions they have, and continue to reiterate her qualifications."

National Economic Council Deputy Director Sameera Fazili and National Security Council Senior Director of International Economics and Competitiveness Peter Harrell joined a White House press briefing to discuss the executive order Biden will sign Wednesday afternoon that will commence an investigation and deliver recommendations to fix supply chain vulnerabilities revealed by the COVID-19 pandemic.

"Make no mistake, we are not simply planning to order up reports. We are going to be taking actions to close gaps as we identify them..." Harrell said.

The executive order will mandate a 100-day review of critical product supply chains in the U.S. focused on those for computer chips, large capacity batteries, active pharmaceutical ingredients and critical minerals and strategic materials, including rare earth minerals.

Fazili argued the investigation could be good for the U.S. economy.

"There are opportunities for small business development to help diversify supplier networks and alleviate the risk of too-big-to-fail companies in the supply chains for critical goods," Fazili said. "There are opportunities to improve worker readiness and training so they have the skills needed to ramp up research, production, or distribution of a critical good."

One hundred and sixty chief executive officers sent an open letter to congressional leadership Wednesday, urging lawmakers to pass "immediate and large-scale federal legislation to address the health and economic crises brought on by the COVID-19 pandemic" on a bipartisan basis.

The letter asks Congress to "to authorize a stimulus and relief package along the lines of the Biden-Harris administration’s proposed American Rescue Plan," perhaps leaving some room for negotiation on what the final package will look like. But the letter makes clear that major business CEOs, including the heads of Morgan Stanley, Visa, United Airlines, BlackRock, Comcast and Google are pushing for relief on the scale of Biden's plan.

"The American Rescue Plan provides a framework for coordinated public-private efforts to overcome COVID-19 and to move forward with a new era of inclusive growth. The country’s business community is prepared to work with you to achieve these critical objectives," the letter says.

Just Tuesday, though, Sen. Mitt Romney, R-Utah, one of the few Senate Republicans who has shown willingness to buck his party, criticized the $1.9 trillion bill in a Wall Street Journal op-ed.

"The $1.9 trillion bill is a clunker. It would waste hundreds of billions of dollars, do nothing meaningful to get kids back to school, and enact policies that work against job creation. The Congressional Budget Office’s recent analysis of the plan found that more than a third of the proposed funding—$700 billion—wouldn’t be spent until 2022 or later, undermining the administration’s claim that the massive price tag is justified for urgent pandemic-related needs," Romney wrote.

Whether the pressure from big business will sway any Republicans in the Senate remains to be seen, but Wednesday morning's messaging from GOP lawmakers is pretty clear: They have no intentions of budging.

-ABC News' Sarah Kolinovsky

The White House will send 25 million masks to more than 1,300 community health centers, food pantries and soup kitchens to deliver for vulnerable communities, it says.

The masks, which are “high-quality, washable, and consistent with the mask guidance from the CDC,” will be delivered by the Department of Health and Human Services, in partnership with the Department of Defense starting in March through May.

“As a result of these actions, an estimated 12 to 15 million Americans will receive masks. More than 25 million masks total will be distributed,” the administration said in the release.

-ABC News' Molly Nagle

The first day of hearings for Biden's pick for secretary of health and human services, Xavier Becerra, kicked off with glowing praise from Democrats, who heralded his experience, and criticism from Republicans, who think his resume is a detractor.

Both Sen. Patty Murray, D-Wash., and Sen. Diane Feinstein, D-Calif., who introduced Becerra, highlighted his potential to make history as the first Latino to lead the department and his experience leading massive departments and in policy as a congressman for 24 years. But Sen. Richard Burr, R-N.C., said he is “not sold” Becerra has the “necessary experience or skills to do this job at this moment.”

Becerra, in his opening statement, said he was committed to working in a bipartisan way.

“No one understands your states and communities better than you. We may not always agree, but if I’m fortunate enough to be confirmed, I will always listen to you and keep an open mind, find common cause, and work with you to improve the health and dignity of the American people,” Becerra said.

Becerra laid out his "vision" for the department with three goals: make COVID-19 treatments more accessible, bring down the cost of health care and restore faith in public institutions by putting science first.

-ABC News' Cheyenne Haslett