Biden signed an executive order Wednesday that will begin a 100-day investigation into vulnerabilities in the supply chain of critical sectors including computer chips, large capacity batteries, active pharmaceutical ingredients and critical and strategic materials, including rare earth minerals.

Biden touted the move as something that will strengthen America for future challenges like the COVID-19 pandemic, which revealed myriad flaws in the supply chain.

"This is about making sure the United States can meet every challenge we face in this new era," Biden said. "Pandemics, but also in defense, cybersecurity, climate change, and so much more. And the best way to do that is by protecting and sharpening America’s competitive edge by investing here at home."

In remarks before the signing, he called the subject one of few "where Republicans and Democrats agreed," having met earlier in the day with a bipartisan group of lawmakers.

Sen. Richard Shelby, R-Ala., a top Republican on the Appropriations Committee, is throwing his weight behind an alternative nominee to head the Office of Management and Budget: Shalanda Young.

Young was nominated by Biden to be deputy director of the Office of Management and Budget. Young was most recently the staff director at House Appropriations, and she and Shelby have a close working relationship.

“I believe she would be good in that role. She’s smart, she knows the process inside-out, and she’s an honest broker who has demonstrated the ability to work with both sides and get things done. She would have my support, and I suspect many of my Republican colleagues would support her, as well," Shelby said in a statement. "But that’s up to the Biden Administration.”

White House press secretary Jen Psaki was asked about Shelby's support on Wednesday and the possibility of Young being a Neera Tanden replacement, but she made clear that the White House maintains support for Tanden.

-ABC News' Trish Turner

Energy and Natural Resources Committee Chairman Sen. Joe Manchin, D-W.V., will vote to confirm Rep. Deb Haaland's, D-Ariz., nomination to serve as secretary of the interior, easing concerns that Haaland's appointment could be in jeopardy.

Manchin has been in close focus on this and other nominations this week, as the moderate Democrat has significant ability to jeopardize nominees in the evenly divided Senate.

Manchin has said he will oppose the nomination of Neera Tanden to the Office of Management and Budget and has not committed to a position on Xavier Becerra's nomination to lead the Department of Health and Human Services.

"I believe that every Presidential nominee and every Member of Congress must be committed to a new era of bipartisanship. That is the standard the overwhelming majority of Americans expect and deserve," Manchin said in a statement. "With respect to Representative Haaland and her confirmation hearing, while we do not agree on every issue, she reaffirmed her strong commitment to bipartisanship, addressing the diverse needs of our country and maintaining our nation’s energy independence."

-ABC News' Allison Pecorin

Biden has officially extended the national emergency declared over the COVID-19 pandemic beyond March 1. By law, the national emergency would have ended a year after it was declared unless the president took action within 90 days of the expiration date.

"The COVID-19 pandemic continues to cause significant risk to the public health and safety of the Nation," Biden wrote in his letter to Congress. "More than 500,000 people in this Nation have perished from the disease, and it is essential to continue to combat and respond to COVID-19 with the full capacity and capability of the Federal Government."

The national emergency was initially ordered by former President Donald Trump on March 13, 2020, freeing up financial resources for the country as the pandemic took hold.

-ABC News' Molly Nagle

Rep. Ted Budd, R-N.C., had a message for Democrats last summer about their proxy voting system set up during the pandemic: it was an "unconstitutional scheme."

"If you use Nancy Pelosi's proxy to skip work, you shouldn't get paid. It's as simple as that," he said in a June 30 Facebook video introducing his new bill withholding member pay for proxy voting.

Budd wasn't alone: A handful of House Republicans previously critical of the proxy vote system submitted letters to have colleagues vote for them, while they were scheduled to appear at CPAC.

Freshman Rep. Madison Cawthorn, R-N.C., tweeted last summer that leaders "show up no matter how uncertain the times are," and that Democrats were "cowards for hiding" and proxy voting.

He was also in Orlando on Friday, telling conservatives activists, "If we sit on the sidelines, we will not have a country to inherit."

"If we do not get involved and say that it is our duty to make sure that our country is responsible, that our country doesn't take away our liberties, then my friends, we will lose this nation," Cawthorn said.

Others Republicans scheduled to appear at CPAC on Friday who also planned to vote by proxy included Reps. Greg Steube of Florida, Virginia Foxx of North Carolina, and Matt Gaetz of Florida, who was one of the first Republicans to support proxy voting.

Curtis Kalin, a spokesman for Budd, said the congressman still opposes proxy voting, and will donate his salary for the days he used the system to a restaurant relief fund, given his bill last year, "The No Pay for Proxy Voting Act."

The Republicans who attended CPAC aren't alone in their questionable use of the proxy voting system -- established by House Speaker Nancy Pelosi, D-Calif., last year to cut down member travel to Washington during the COVID-19 pandemic.

Last year, Rep. Greg Stanton, D-Ariz., was caught voting during a Transportation Committee hearing from a boat during a family trip to Utah. Stanton later apologized and said he "messed up." And several House Democrats voted by proxy last May in order to attend a SpaceX rocket launch in Florida.-ABC News' Benjamin Siegel