"Our country is in decline," DeSantis said in response to the first debate question, on the economy. "This decline is not inevitable. It's a choice. We need to send Joe Biden back to his basement and reverse American decline."

DeSantis also took a swipe at the president's son Hunter, criticizing Hunter for selling high-priced artwork while other people are struggling to afford groceries.

"It starts with understanding we must reverse Bidenomics so that middle-class families have a chance to succeed again," DeSantis said, referring to the name that the White House has used to popularize what they see as the president's successful platform.

I am here in Milwaukee in the spin room. If you think journalism is glamorous, let me disabuse you of that notion. The media is being housed in what is essentially a parking garage at the FiservForum and the bathrooms are outside porta-potties. By the way, it was a 100-degree day in Milwaukee, so just going to the bathroom is a bit of an experience. And yes, I would like some Wisconsin cheese with my whine. Anyway, I'll be quiet about the plight of the reporters, we are here to hear about the plight of Americans and what these candidates have to say about it. Let's begin!
–Analysis from Galen Druke of FiveThirtyEight

The Biden-Harris campaign appeared to buy airtime on Fox News ahead of the GOP primary debate, with ad advertisement for the Democrats’ reelection campaign running just minutes before the eight Republican hopefuls took the stage.

The ad, which acted as something of counter-programing to what the GOP hopefuls may discuss during the two-hour debate, touted what the Biden administration sees as its legislative accomplishments, like the American Rescue Plan, the Inflation Reduction Act, the CHIPS and Science Act and the Bipartisan Infrastructure Law.

The spot highlighted the economy under Biden, which is likely contrary to what the Republican primary candidates will raise on stage -- citing Biden's low marks from voters on his handling of economic issues.

–ABC News’ Isabella Murray

I’m monitoring Christie and Scott tonight. Even though the two candidates are polling similarly in the 3 to 4 percent range in FiveThirtyEight’s national polling average, they are a subject in contrasts. Although Pence has been more vocally critical of Trump recently, Christie is the most high-profile, full-on anti-Trump candidate on stage. Realistically, Christie has very little chance at the GOP nomination because he has negative net favorability ratings among Republicans. But that may mean he will focus almost entirely tonight on attacking Trump rather than making appeals to the party base. As a result, Christie could be a popular foil for the contenders on stage who have largely eschewed going after Trump, or have even defended him.

Meanwhile, Scott arguably has one of the highest ceilings of any candidate on stage. He’s not nearly as well-known to GOP voters as Trump or DeSantis, but Scott gets rave reviews from Republicans who are familiar with him. That means tonight is an opportunity for him to expand his reach and also potentially increase the share of GOP primary voters who would consider voting for him. I’ll be interested to see how much he leans into his “happy warrior” image as a means of differentiating himself from DeSantis and Ramaswamy, and whether he tries to rise above the fray to some extent if some of the other candidates — especially Christie — get into verbal fisticuffs.

–Analysis from Geoffrey Skelley

Members of DeSantis’s campaign are still upset about a debate memo that was prepared and published last week by a super PAC supporting the governor, a source close to the campaign told ABC News on Wednesday, describing those members of his team as “wildly irritated.”

Chief among the complaints is that the memo, which detailed suggested approaches and lines of attack, effectively handcuffs DeSantis by preventing the governor from using any of the advice on stage lest he invite attacks from opponents for using lines manufactured for him by other people.

The memo included research documents that show that Axiom Strategies, a consulting firm tied to the super political action committee, anticipated that the biggest hits to DeSantis would include his battle with Disney -- ABC News' parent company -- past comments on Ukraine, Florida's Black history standard, the culture wars and abortion.

The packet also included past comments made by presidential hopefuls attacking DeSantis on those specific subjects.

DeSantis himself has downplayed the memo, telling Fox News recently, “It’s not mine. I haven’t read it. It’s just -- I think it’s something that we have put off to the side.”

-ABC News’ Hannah Demissie, Will McDuffie and Olivia Osteen