Biden vowed to protect the Affordable Care Act, aka Obamacare, which he said provides health insurance to more than 100 million people who would otherwise be denied it due to pre-existing conditions.

"But my predecessor and many in this chamber want to take that protection away by repealing the Affordable Care Act," he said, as some in the chamber booed. "I won’t let that happen!"

"We stopped you 50 times before and we will stop you again!" he continued.

Republicans have for years tried and fail to repeal and replace the law, which has grown increasingly popular with the public.

In addition to protecting Obamacare, Biden said he wants to expand it by making permanent tax credits set to expire next year that save families $800 annually.

Biden touted efforts to make housing more affordable, including helping Americans have enough money to obtain a federally backed mortgage.

"My administration is also eliminating title insurance on federally backed mortgages. When you refinance your home, you can save $1,000 or more as a consequence," he said.

"I know the cost of housing is so important to you. As inflation keeps coming down, mortgage rates will come down as well…but I'm not waiting. I want to provide an annual tax credit that will give Americans $400 a month for the next two years as mortgage rates come down to put toward their mortgage when they buy their first home or trade up for a little more space."

Biden took a moment to introduce United Auto Workers (UAW) President Shawn Fain, who endorsed him for reelection, while speaking about the power of unions in America.

Biden praised unions for building up the middle class.

"Wall Street didn't build America. They’re not bad guys, they didn't build it though," Biden said. "The middle class built the country and unions built the middle class!"

Addressing the Nation, Biden said, "I say to the American people, when America gets knocked down, we get back up! We keep going! That's America!"

Last year, the Biden administration unveiled the first set of prescription drugs that are subject to price negotiations with Medicare -- a milestone for Democrats in their yearslong push to lower rising health care costs.

He celebrated the effort, telling the crowd: "With a law I proposed and signed and not one Republican voted for we finally beat Big Pharma."

"Now it’s time to go further and give Medicare the power to negotiate lower prices for 500 drugs over the next decade," Biden proposed. "That will not only save lives it will save taxpayers another $200 billion."