Late into Biden's remarks, a man was removed from the upper area of the House chamber after shouting out repeatedly.

The man appeared to be yelling about the Marines who were killed in the Abbey Gate bombing at the airport in Kabul, Afghanistan, during the U.S. withdrawal in 2021.

Biden's handling of the American exit was criticized by many at the time, though he has defended ending the protracted and divisive war.

-ABC News' Adam Carlson

Biden departed from his prepared remarks while discussing his border policy after the name Laken Riley was called out, as some in the GOP have blamed the White House's handling of immigration for Riley's death.

The 22-year-old Georgia nursing student was killed last month -- allegedly by a Venezuelan migrant whom officials say was illegally in the U.S.

"Laken Riley! An innocent young woman who was killed by an illegal," Biden said while holding up a Laken Riley pin.

Addressing her parents, he said. "My heart goes out to you having lost children myself."

He said Republicans owe it to Americans to "get this bill done," referring to a Senate agreement to tighten immigration restrictions, which some conservatives say is insufficient to fix the problem.

Biden reiterated his call for Congress to enact stricter gun reform, including banning high-capacity magazines and assault rifles -- while swiping at former President Donald Trump.

"After another school shooting in Iowa [Trump] said we should just 'get over it.' I say we must stop it," Biden said.

"I’m demanding a ban on assault weapons and high-capacity magazines! Pass universal background checks! None of this violates the Second Amendment or vilifies responsible gun owners."

Biden reiterated his calls for several policies at the heart of his domestic agenda, though they are unlikely to become law in this divided Congress.

He urged lawmakers to pass the Equality Act, which would prohibit discrimination against the LGBTQ+ community; the PRO Act, which would protect workers' rights; and the Freedom to Vote Act and the John Lewis Voting Rights Act to bolster voting rights.

"And raise the federal minimum wage because every worker has the right to earn a decent living," he said.

Hi, I’m Monica Potts, a senior political reporter at 538. I’ll be watching the State of the Union and helping provide analysis and commentary about some of the themes from Biden’s speech. I’ll be especially interested in what he has to say about abortion, foreign policy, democracy and the economy. As my ABC News colleagues have noted, the night is really a sort of campaign kickoff event, and how he frames those issues could preview how he plans to talk about them with voters.

I’ll be able to provide context on how voters think about those issues as well. While my colleagues at 538 and I know that the State of the Union itself tends not to move the needle politically, the speech can tell us where Biden plans to focus his efforts this election year. It’s also an opportunity for Biden to assuage concerns from his own voters and inspire them to vote in November. The presidential race has the potential to be as close as the last two, so he’ll need it if he wants to win.

-Monica Potts, 538