Sen. Marsha Blackburn, R-Tenn., focused her remarks on the rhetoric around Barrett as a woman and mother, questioning why her Democratic colleagues aren’t more supportive of someone she called a “successful female legal superstar.”

“Given your track record, you would think that my colleagues would jump at the opportunity to support a successful female legal superstar, who is highly regarded by both her Democratic and Republican colleagues, and who is a working mom. But as today's increasingly paternalistic and frankly disrespectful arguments have shown, if they had it their way, only certain kinds of women would be allowed into this hearing room," Blackburn said.

“On that note, not so long ago in another hearing they scrutinized your commitment to your Catholic faith and tried to use that as a way to question your competency and your professionalism,” Blackburn said, referring to Judge Barrett’s confirmation hearing to a federal appeals court in 2017, though Barrett's faith has not yet been raised by Democrats in her Supreme Court nomination.

Blackburn, as several of her GOP colleagues before her had done, raised the Justice Kavanaugh hearings and deemed the sexual assault allegation against Kavanaugh another effort “to delay and obstruct legitimate constitutionally sound confirmation hearing.”

“Let's not forget it was the Democrats who took an axe to the process in 2018 when they dropped last-minute, unsubstantiated sexual assault allegations against Justice Kavanaugh. We still don't have the full story about their level and manner of coordination with activists and mainstream media outlets, but what we do know is that they turned that confirmation into a circus.”

Sen. Kamala Harris, D-Calif., has the historic opportunity this week to question a Supreme Court nominee while on the ticket of a major political party. Appearing virtually, she began her opening statement by criticizing Senate Republicans for holding the hearing and disregarding, she said, the health and safety of Capitol staff.

“The decision to hold this hearing now is reckless and places the facility's workers, janitorial staff and congressional aides and Capitol police at risk, not to mention that while tens of millions of Americans are struggling to pay their bills,” Harris said. “The Senate should be prioritizing coronavirus relief and providing financial support to those families.”

Harris said if Republicans succeed with their nomination, they will likely eliminate protections for 135 million Americans with pre-existing conditions --without regard for the legacy of Justice Ginsburg.

"By replacing Justice Ruth Bader Ginsburg with someone who will undo her legacy, President Trump is attempting to roll back Americans' rights for decades to come,” Harris said. “Every American must understand that with this nomination equal justice under law is at stake. Our voting rights are at stake. Workers' rights are at stake. Consumer rights are at stake. The right to a safe and legal abortion is at stake. And holding corporations accountable is at stake.”

After Harris wrapped, Barrett's children and sisters reentered the hearing room, in a sign that Barrett's opening statement isn't far off.

More on other key questions the court will consider this term can be found here.

Sen. Cory Booker, D-N.J., said in his opening statement that Republicans are rushing through the process with the ultimate goal of overturning not just the Affordable Care Act but Roe v. Wade, calling the whole hearing “a charade.”

“President Trump has explicitly stated he would only put up Supreme Court nominees that would overturn Roe V. Wade. He said it clearly. We should believe him,” Booker began.

“We're here because in the middle of an ongoing election, Republicans have found a nominee in Judge Barrett, to do what they couldn't do, subvert the will of the American people and overturn the ACA and overturn Roe v. Wade,” Booker said. “That's what this is about.”

In an appeal across the aisle, Booker reminded, “If one of my colleagues will stand up on this committee, we will hold this over until after the election," before ripping into the process.

“It's not normal the senators are rushing through a confirmation hearing, violating their own words and their own statements, betraying the trust of the American people and their colleagues and failing to take in this hearing, the most basic safety protections to protect people around them, all to ensure that tens of millions of people will lose their health care when we're seven months into one of the worst public health crises in our country,” Booker concluded.

Sen. Joni Ernst, R-Iowa, facing a tight reelection fight, went after Democrats for what she called attacks on Judge Barrett’s Catholic faith -- as her colleague Sen. Hawley had done before -- yet no Democrats have raised her Catholic faith in the hearing so far.

“This week will be an opportunity to dig into your background further and understand more about your judicial philosophy,” Ernst said to Barrett. “But what your political opponents want to paint you as is a TV or cartoon version of a religious radical. A so-called 'handmaid' that feeds into the ridiculous stereotypes they set out to lambaste people of faith in America.”

“They are attacking you as a mom and a woman of faith because they cannot attack your qualifications,” she added.

Ernst, who has served in the Senate since 2015, also said, “It frustrates me and it frustrates my fellow Iowans that the Supreme Court has become a super legislature for a Congress that, frankly, won't come together and discuss the tough issues and do its job.”