Sen. Sheldon Whitehouse, D-R.I., deemed Judge Barrett’s nomination and President Donald Trump’s inability to keep the White House safe from COVID-19 both “an irresponsible botch.”

“America is worried about one thing above all else right now and it's our health. This hearing itself is a microcosm of Trump's dangerous ineptitude in dealing with the COVID pandemic. Trump can't even keep the White House safe. Here it's the chairman's job to see to the committee's safety. And though his words were reassuring, I don't know who has been tested,” Whitehouse said, noting that Graham didn't release the results of a second test.

“The whole thing, just like Trump, is an irresponsible botch. The irony is that this slapdash hearing targets the Affordable Care Act,” Whitehouse said.

He went on to say Americans see this nomination as an “ugly hasty hypocritical power grab” and that “they know what it means for their health care in the midst of a pandemic.”

“For Republicans, there is no washing your hands of responsibility for the results that your president has told us will ensue,” he added.

Sen. Mike Lee, R-Utah, who tested positive for coronavirus after Judge Barrett’s Rose Garden nomination event on Sept. 26, appeared in-person and delivered his opening statement without a mask, despite heightened COVID-19 fears on Capitol Hill.

He used his time to criticize the “politicization” of Judge Barrett’s nomination and reminded colleagues that Barrett is a judge, not a policymaker, and should be asked questions accordingly.

“These tactics of creating fear and uncertainty and doubt, these tactics that result in relentless protests outside of the one branch of government that isn't political astound me, dismay me and disappoint me. They reflect the fact that we have allowed for the politicization of the one branch of the federal government that is not political,” Lee said.

“We ourselves within the legislative branch have got to do a better job by focusing on the fact that the Constitution is not just a judicial thing. It's also a legislative thing. It is also an executive thing. It is an American thing. It's one of the many reasons why I will object to anyone, anytime anyone tries to attribute to you a policy position and hold you to that,” he concluded.

Lee’s presence would appear to violate Centers for Disease Control and Prevention isolation guidelines as he tested positive for COVID-19 on Oct. 2, just 10 days ago.

"Good news," said Graham, leading the hearing. "Senator Lee's enthusiasm for the dormant Commerce Clause convinces me you have made a full recovery."

Sen. John Cornyn, R-Texas, said he hopes Democrats don’t use the hearing to attack Judge Barrett’s Roman Catholic faith, arguing Democrats' raising Justice Brett Kavanaugh’s Catholic faith at his hearing was “an absolute disgrace.”

“I hope they resist the temptation to repeat that during this hearing. I do remain concerned, Judge, about some of the earlier attacks on your faith,” he said. “Let me be clear, Judge, as you know, there's no religious test to serve on the Supreme Court. Why? Because the Constitution says so. And I can only hope that the civility that you have shown through your professional work will be afforded to you through these proceedings.”

Cornyn said his constituents are more concerned with her family life -- “how you do it," he said, referring to juggling personal and professional responsibilities.

“How do you and your husband manage two full-time professional careers, and at the same time, take care of your large family? I bet there are many young women like my own two daughters who marvel at the balance that you've achieved between your personal and professional life,” he said.

Sen. Dick Durbin, an Illinois Democrat, noted the bipartisan confirmation votes of Justices Ginsburg and Scalia raised earlier -- before dismissing the chance of that in the current Senate.

“The reason those votes were so overwhelming was because people lived by the rules. They lived by the traditions of the Senate and they had mutual respect for one another. We know now that this process does not adhere to those guidelines,” Durbin said, arguing that the nomination was rushed and noting some background paperwork on Barrett is still missing.

“Their haste, the haste in this pursuit set before us today is unfair to the Senate and unfair really to the nominee,” he said.

Durbin then outlined the “McConnell Rule.”

"On February 13, 2016, when Justice Scalia passed away, Senator McConnell said at the time, “The American people should have a voice in this election of their Supreme Court Justice. Therefore, this vacancy should not be filled until we have a new president.”

“In 2016, Senator McConnell says give them a voice. Now he says don't give them a voice. It is a shameless self-serving reversal,” Durbin said, noting the election is 22 days away.

“Why are Senate Republicans so afraid to give the American people a voice about the future of the Supreme Court? First they must doubt that Donald Trump will be re-elected. Second, they want a 6-3 Supreme Court to carry out a Republican agenda that is really not very popular with the American people,” Durbin said, raising the Affordable Care Act and election-related cases that may come before the Court, and using his constituents to put a face to the debate.

“Judge Barrett, your nomination for the highest court in the land comes under a cloud. You've been nominated by a president who shows contempt for the Constitution, but does not hesitate to tell his loyal followers you are being sent to the bench to do his political chores. Abolish the ACA, rule in his favor, and more,” Durbin concluded. “You cannot feel good about a president cheapening this historic moment.”

Supreme Court nominee Judge Amy Coney Barrett will focus on her family, morals and judicial philosophy when she appears before the Senate Judiciary committee Monday, according to a copy of her opening statement released Sunday.

The 48-year-old judge on the Seventh Circuit Court of Appeals, Notre Dame law professor and mother of seven wrote in her statement that she was "used to being in a group of nine -- my family."

Barrett, who was nominated to fill the seat left vacant by the late Justice Ruth Bader Ginsburg, references the lessons she learned from the late Supreme Court Justice Antonin Scalia, particularly as it pertains to her interpretation of the law, in her statement.

"The policy decisions and value judgements of government must be made by the political branches elected by and accountable to the people," Barrett's statement reads. "The public should not expect courts to do so, and courts could not try."

-ABC News' Allison Pecorin