The four days of Supreme Court confirmation hearings held by the Senate Judiciary Committee will look vastly different than previous hearings because of COVID-19 restrictions.

Sen. Mike Lee, R-Utah, and Sen. Thom Tillis, R-N.C., tested positive for the coronavirus after attending the White House Rose Garden ceremony to announce Barrett's nomination. As a result, members have the option of participating in the hearings remotely. Barrett is expected to appear in person, Lee is "undecided" and Tillis said Tuesday on Fox News that he anticipated attending some days of the hearing virtually.

On Friday, Sens. Kamala Harris, D-Calif., Patrick Leahy, D-Vt., and Cory Booker, D-N.J., sent a letter to Graham demanding "stringent" testing for all those in attendance. Sen. Joni Ernst, R-Iowa, tweeted that she also supported testing for members. But Graham has not responded.

Leahy, who is 80 years old, has decided to stay away from the hearings because of Graham's failure to respond. He and Harris have said they will participate remotely as a result.

Democrats are expected to mount additional challenges to safety of the hearing's proceedings, an official confirmed to ABC News.

Masks are now a mainstay of hearings on the Hill.

Long lines of spectators snaking through the halls of the Hart Senate Office Building waiting to get a glimpse of the proceedings will also be gone as the public will not be allowed inside. Only members, Barrett's guests, staff and journalists will be permitted.

Members who do appear will do so in bursts, an official confirmed to ABC News. They may appear to question Barrett but must return to their offices to watch the remainder of the hearing from a more isolated location.

-ABC News' Allison Pecorin

Amy Coney Barrett, if confirmed to the U.S. Supreme Court, would be the nation's 115th justice of SCOTUS and the first woman of school-aged children to serve on the nation's highest court.

No nominee has ever been confirmed by Congress this close to the election.

-ABC News' Trish Turner

Supreme Court nominee Judge Amy Coney Barrett will focus on her family, morals and judicial philosophy when she appears before the Senate Judiciary committee Monday, according to a copy of her opening statement released Sunday.

The 48-year-old judge on the Seventh Circuit Court of Appeals, Notre Dame law professor and mother of seven wrote in her statement that she was "used to being in a group of nine -- my family."

Barrett, who was nominated to fill the seat left vacant by the late Justice Ruth Bader Ginsburg, references the lessons she learned from the late Supreme Court Justice Antonin Scalia, particularly as it pertains to her interpretation of the law, in her statement.

"The policy decisions and value judgements of government must be made by the political branches elected by and accountable to the people," Barrett's statement reads. "The public should not expect courts to do so, and courts could not try."

-ABC News' Allison Pecorin

Six in 10 registered voters say the U.S. Supreme Court should uphold Roe v. Wade as the basis of abortion law in the United States, and a majority in an ABC News/Washington Post poll -- albeit now a narrow one -- says the Senate should delay filling the court's current vacancy.

Sixty-two percent in the national survey say they would want the court to uphold Roe, while 24% would want it overturned; 14% have no opinion. There are broad political, ideological and religious-based divisions on the question.

Separately, 52% say filling the seat opened by the death of Ruth Bader Ginsburg last month should be left to the winner of the presidential election and a Senate vote next year. Forty-four percent instead say the current Senate should vote on Trump's nomination of Amy Coney Barrett to the position.

That's a closer division than the 57%-39% preference for waiting in an ABC/Post poll late last month. That poll was conducted before Trump nominated Barrett and the Senate moved to proceed with her confirmation hearings, scheduled to start Monday.

Opposition to action has dropped among political independents, from 63% to 51%. Eighty-three percent of Democrats favor waiting to fill the seat, while 77% of Republicans in this poll, produced for ABC by Langer Research Associates, support action now.

Similarly, 77% of conservatives want action by the current Senate; 64% of moderates and 87% of liberals say wait. Among registered voters who want Roe upheld, 68% say the Barrett nomination should be set aside; among critics of Roe, 71% want the Senate to proceed.

Read more about the new ABC News/Washington Post poll here.

-Gary Langer of Langer Research Associates, conducted the poll.

Sen. Marsha Blackburn, R-Tenn., focused her remarks on the rhetoric around Barrett as a woman and mother, questioning why her Democratic colleagues aren’t more supportive of someone she called a “successful female legal superstar.”

“Given your track record, you would think that my colleagues would jump at the opportunity to support a successful female legal superstar, who is highly regarded by both her Democratic and Republican colleagues, and who is a working mom. But as today's increasingly paternalistic and frankly disrespectful arguments have shown, if they had it their way, only certain kinds of women would be allowed into this hearing room," Blackburn said.

“On that note, not so long ago in another hearing they scrutinized your commitment to your Catholic faith and tried to use that as a way to question your competency and your professionalism,” Blackburn said, referring to Judge Barrett’s confirmation hearing to a federal appeals court in 2017, though Barrett's faith has not yet been raised by Democrats in her Supreme Court nomination.

Blackburn, as several of her GOP colleagues before her had done, raised the Justice Kavanaugh hearings and deemed the sexual assault allegation against Kavanaugh another effort “to delay and obstruct legitimate constitutionally sound confirmation hearing.”

“Let's not forget it was the Democrats who took an axe to the process in 2018 when they dropped last-minute, unsubstantiated sexual assault allegations against Justice Kavanaugh. We still don't have the full story about their level and manner of coordination with activists and mainstream media outlets, but what we do know is that they turned that confirmation into a circus.”