AFC SOUTH
Indianapolis Colts: The Colts were so high on center Ryan Kelly that they took him in the first round. The belief is that he'll end the revolving door at that position. He's about to become the sixth -- and hopefully final -- starting center the Colts have used since drafting quarterback Andrew Luck in 2012. Kelly was named the nation's top center last year at Alabama. -- Mike Wells
Jacksonville Jaguars: Jalen Ramsey, the No. 5 overall pick, played multiple spots at Florida State but will strictly be a cornerback with the Jaguars. He has the size, length and physicality to play the kind of press-man coverage the Jaguars want out of their corners, and he will immediately step into a starting spot opposite Davon House. Ramsey will have more chances to make plays than he did at FSU because teams won't avoid throwing at him. His presence will help a still-developing pass rush, too. -- Mike DiRocco
Tennessee Titans: After trading from No. 1 to No. 15, the Titans traded back up to No. 8 to take offensive tackle Jack Conklin. He should take over the right tackle spot and bring a mauling style to a position where the Titans are in dire need of top-flight pass protection and run-blocking. The Titans expect high-quality performance that is contagious. -- Paul Kuharsky
AFC WEST
Kansas City Chiefs: Any of the three cornerbacks drafted by the Chiefs have the best chance to be the team's top rookie because they'll get a shot at significant playing time. Of that group, I'll give the nod to third-round pick KeiVarae Russell because he was picked ahead of Eric Murray (fourth round) and D.J. White (sixth round). The Chiefs' top pick, second-round defensive tackle Chris Jones of Mississippi State, probably won't be an immediate starter. -- Adam Teicher
Oakland Raiders: Karl Joseph is a "perfect fit for what we want to accomplish here," Raiders assistant defensive backs coach and Hall of Famer Rod Woodson told me. And as long as the undersized but hard-hitting strong safety with soft hands is fully healed from the knee injury that limited him to four games last season, Oakland's first-round draft pick will be starting and, thus, have the biggest immediate impact among the Raiders rookies. -- Paul Gutierrez
San Diego Chargers: It will be first-round selection Joey Bosa. The Chargers drafted who they believe is the most pro-ready player of the class in the Ohio State defensive end. After finishing 4-12 last season, San Diego needs Bosa to come in and help fix what was one of the worst run defenses in football last season. Bosa also should help energize the team's fan base, with the Chargers looking to build support to finance a new football stadium in town. -- Eric D. Williams
NFC EAST
New York Giants: Second-round wide receiver Sterling Shepard is in the best position to make a significant impact. The Giants targeted him early in the draft process as a wideout they liked, and coach Ben McAdoo sees him as a player he can use all over the formation in a variety of roles as a complement to star Odell Beckham Jr. With Rueben Randle gone and Victor Cruz still a major question mark as he attempts his comeback from knee and calf injuries, there's an opening for a No. 2 wide receiver in New York. Shepard will get every opportunity to lock down the role for the short and long term, and he has the skill set to do it. -- Dan Graziano
Philadelphia Eagles: In terms of playing this year, the draft pick with the biggest impact is likely to be running back Wendell Smallwood. He's a fifth-round pick, but new coach Doug Pederson likes what Smallwood brings to the offense. No. 2 overall pick Carson Wentz, however, will have the biggest impact on the Eagles in 2016, even if he never takes the field. The Eagles' season will be all about when Wentz is ready and how Pederson manages the whole quarterback situation. -- Phil Sheridan
Washington Redskins: It's tough to ignore second-round pick Su'a Cravens because the hybrid linebacker/safety will have an immediate role in the Redskins' nickel and dime packages. But they absolutely love receiver Josh Doctson, their first-round pick. Even though he'll be a backup to DeSean Jackson and Pierre Garcon, the Redskins will use him quite a bit, especially in the red zone. He gives them something they didn't have last season: a receiver with a little height (6-foot-2) and fantastic leaping ability. Plus, his impact will be felt in the long term, allowing either Jackson or Garcon to walk next offseason. -- John Keim
NFC NORTH
Detroit Lions: The Lions are expecting Taylor Decker, the team's first-round pick, to make an impact right away on an offensive line that struggled the past two seasons. He could end up as the Day 1 starter at right tackle and might push Riley Reiff to become the team's left tackle. That's where Detroit hopes his future will be -- if not in 2016, then in the long term. The Lions need Decker to be immediately successful for their offense to improve. -- Michael Rothstein
Green Bay Packers: Coach Mike McCarthy always says third down is the most important down in football. And that's when fourth-round pick Blake Martinez could get the chance to shine. The Packers are looking for an inside linebacker who can run and cover. That's exactly what they hope Martinez will be as a rookie. -- Rob Demovsky
Minnesota Vikings: The Vikings' draft class is such that most of their rookies don't have to contribute this year, but there's one notable exception: The league's 31st-ranked passing offense needs first-round pick Laquon Treadwell to step in and become a go-to receiver target for Teddy Bridgewater. It would be surprising not to see the 23rd overall pick play a major role in the offense this year; the Vikings drafted him in part because he already excels at some of the routes they frequently use. He'll be asked to step in and give the offense an immediate boost. -- Ben Goessling
NFC SOUTH
Carolina Panthers: I'm going to hedge and say either second-round pick James Bradberry or third-round pick Daryl Worley. Both are 6-foot-1 cornerbacks and both were selected in hope that one can replace 2015 Pro Bowl selection Josh Norman. Bradberry didn't face much big-time competition at Samford, but the Panthers thought enough of him to take him a round higher than Worley, who played at West Virginia. I'm leaning toward Worley on this one just because he's faced more big-time programs. Then again, Norman came from a small school, too. First-round pick Vernon Butler, meanwhile, should help make life easier for the young corners as part of the defensive tackle rotation with Pro Bowler Kawann Short and Star Lotulelei. -- David Newton
New Orleans Saints: Defensive tackle Sheldon Rankins is an easy, obvious choice here. Not only was Rankins the best player the Saints drafted, but their first-round pick also filled the biggest need of anyone they selected. New Orleans' defensive line needs to become much more disruptive after allowing more yards per rush and more yards per pass than any other team in the NFL last season. Rankins (6-foot-1, 299) has the versatility to help in both areas immediately after racking up 14 sacks and 26.5 tackles for loss over the past two years at Louisville. -- Mike Triplett
Tampa Bay Buccaneers: Outside linebacker Noah Spence was arguably the best pass-rusher in the draft, and he slipped to the second round because of character concerns. The Bucs obviously felt confident enough in him to take him, and the gamble may pay off big time. Spence is a pure edge rusher, which the Bucs don't have. They play six games per season against quarterbacks Drew Brees, Matt Ryan and Cam Newton, so getting pressure is vital if the defense is going to improve. If Spence is as good as many think he is, he'll make a major impact. -- Mike DiRocco
NFC WEST
Los Angeles Rams: Not only should No. 1 overall pick Jared Goff be the obvious choice as the Rams' best rookie in 2016 -- as the likely starting quarterback, he'd better be. Sure, the Rams added some intriguing rookies in the later rounds, but Goff is the franchise. Though they have to protect him as much as possible, they're also counting on him to be the piece that helps them get over the hump and into playoff contention. It's unfair to expect big production as Goff transitions to the NFL, but that's the responsibility that comes with being the first pick for a team that gave up six premium picks to acquire his services. -- Nick Wagoner
San Francisco 49ers: DeForest Buckner fell into the Niners' laps at No. 7 overall and, well, the 49ers plan on him being in opposing quarterbacks' grills all season long. He is a physical specimen at 6-foot-7, 291 pounds and a matchup nightmare as an end in a 3-4 defense, as evidenced by his 10.5 sacks last year at Oregon. Chip Kelly was hired to fix the Niners' offense, but Buckner will have the biggest immediate impact of any of their rookies, and not just on defense. -- Paul Gutierrez
Seattle Seahawks: It's rare for general manager John Schneider to trade up. But when Alabama defensive tackle Jarran Reed started to slip in the second round, Schneider made a move, and the Seahawks were able to get the player they believe is the best run-stuffing defensive lineman in the draft. Reed is the favorite to be the starting nose tackle from Day 1, taking over for Brandon Mebane. Pete Carroll believes that great defense begins with stopping the run and eliminating big plays. Reed is ready to help with the first part of that immediately. -- Sheil Kapadia