Hurricane Ian updates: Florida death toll climbs
Lee County, which encompasses Fort Myers, accounts for most of the fatalities.
The remnants of Ian are charging up the East Coast on Saturday after making landfall as a Category 1 hurricane in South Carolina on Friday afternoon.
The monster storm made its first U.S. landfall on Wednesday on Florida's west coast as a powerful Category 4 hurricane, shredding homes with ferocious winds topping 150 mph. Florida's death toll has climbed to at least 81, according to information from local officials.
Latest headlines:
Ian’s eyewall moving on shore
Hurricane Ian’s eyewall is moving on shore.
The powerful Category 4 storm is set to bring catastrophic storm surge, winds and flooding.
Sanibel Island has reported sustained winds of 58 mph with a wind gust reaching 75 mph.
Over 2,000 flights canceled
The airports in Orlando, Miami, Tampa and Fort Lauderdale are leading the world in flight cancellations Wednesday morning.
Over 2,000 flights have been canceled within, into, or out of the United States on Wednesday.
Another 1,600 flights are already cancelled for Thursday.
The Tampa International Airport will remain closed through Thursday.
-ABC News’ Ahmad Hemingway and Sam Sweeney
Hurricane-force winds approaching Florida coast
Hurricane-force winds are approaching the coast of Florida near Sanibel Island, which is 23 miles from Fort Myers.
FEMA Administrator Deanne Criswell stressed Wednesday the danger of water as Hurricane Ian approaches.
She urged Floridians to never drive through floodwaters, noting a car can be carried away in just a few inches of water.
“From coastal storm surge to inland flooding, the majority of the state of Florida is in Ian’s crosshairs,” she said.
18 feet of storm surge possible
Up to 18 feet of dangerous storm surge is forecast along Florida’s Southwest coast, including Englewood, Bonita Beach and Charlotte Harbor.
FEMA Administrator Deanne Criswell warned Tuesday that her biggest concern with Ian was storm surge.
"In 2018, when Hurricane Michael impacted the Florida Panhandle, there were five recorded fatalities as a result of storm surge,” she noted.
Caribbean Islands to start experiencing effects from Ian by Monday
Caribbean islands such as Jamaica and Grand Cayman will start to experience the effects from the outer bands of Tropical Storm Ian within the next 24 hours, forecasts show. The islands will experience conditions such as heavy rain, possible flash flooding and storm surge.
The storm system will begin to rapidly intensify overnight into Monday before it closes in on western Cuba on Monday night.
As of 2 p.m., the sustained winds in the tropical storm remained at 50 mph as it moved west-northwest at 12 mph, the center about 265 miles away from Grand Cayman.
Hurricane warnings are in effect for Grand Cayman and western Cuba, while tropical storm warnings and watches are in effect in other portions of both islands.
As a hurricane, Ian is expected to peak at a Category 4 before weakening slightly as it looks to make landfall on the west coast or panhandle of Florida in the coming days.
There is still some uncertainty to the track Ian will take once the system enters the Gulf of Mexico.
The center of the storm and the worst of the impacts could end up heading toward the western coast of Florida's peninsula, including the Tampa area. The other possible scenario has the storm moving more due north and bringing a possible landfall along the Florida peninsula, impacting cities like Panama City and Tallahassee with more direct effects.
The storm will begin to impact the Florida keys and the southern portions of the state by Tuesday night.
-ABC News' Dan Peck