Hurricane Ian is now 60 miles southeast of Charleston, South Carolina, with sustained winds of 85 mph and even higher gusts.

Conditions at landfall, which is expected after 2 p.m., are forecast to be worst in Myrtle Beach. The worst of the storm surge will be from there to the North Carolina border.

More than 4 inches of rain has fallen in South Carolina so far and it is expected to continue.

-ABC News' Max Golembo

Tampa International Airport, St. Pete-Clearwater International, Orlando International Airport and Jacksonville International Airport are all set to reopen Friday.

Tampa's first flight is scheduled to arrive at 10:35 a.m. and Orlando will resumer passenger flights after noon. The reopening will be gradual. Orlando already has 445 canceled flights today. Tampa has 152 canceled as of 9:45 a.m.

Jacksonville reopened its Transportation Security Administration checkpoint at 7 a.m. and the airport will be on a reduced operating schedule Friday.

The Federal Aviation Agency closed the Fort Myers airspace to provide a safe environment for search and rescue. It will remain closed Friday.

The Fort Myers Airport will be closed for days, with the FAA saying it won't reopen until at least Oct. 7. United Airlines has canceled all flights out of the airport at least through Monday.

The airports with the most cancelations Friday are Orlando, Tampa and Charlotte, North Carolina.

-ABC News' Sam Sweeney

There are 1.9 million customers are still without power in Florida, Gov. Ron DeSantis said at a press conference Friday.

The hardest hit area is Hardee County, in central Florida, where 99% of customers are without power. Electricity has been restored to 15% of Lee and Charlotte counties, where Ian had knocked out power entirely. Eighty percent of DeSoto County is also without power.

DeSantis said over 42,000 linemen and associated personnel are on the ground, working to restore power.

Lee County is also entirely without water after the storm caused a water main break, DeSantis said.

Tropical storm force winds are lashing much of the coast of the Carolinas before Hurricane Ian is expected to make landfall. Life-threatening storm surge and hurricane conditions are expected by Friday afternoon.

Still over water, Hurricane Ian has reached maximum sustained winds of 85 mph.

Power outages have already begun, with 11,750 South Carolina customers and 8,095 North Carolina customers without electricity.

-ABC News' Max Golembo and Jianna Cousin

There is potentially major flooding in Orange and Seminole counties and St. Johns River, potentially up to Jacksonville in northeast Florida, Gov. Ron DeSantis said Thursday.

"The amount of water that's been rising and will likely continue to rise today, even as the storm is passing, is basically a 500-year flood event. And I know Seminole County has done evacuations, I know they've opened shelters, but we're gonna see a lot of images about the destruction that was done in southwest Florida and obviously we have massive assets there," DeSantis said.

"This storm is having broad impacts across the state and some of the flooding you're going to see in areas hundreds of miles from where this [storm] made landfall are going to set records. And that's going to obviously be the things that will need to be responded to," DeSantis added.

The damage caused by the storm will likely take years to repair, he said.

"You're looking at a storm that's changed the character of a significant part of our state. And this is going to require not just emergency response now, in the days or weeks ahead. I mean, this is going to require years of effort to be able to rebuild and to come back," DeSantis said.