Hurricane Ian updates: Florida death toll climbs
Lee County, which encompasses Fort Myers, accounts for most of the fatalities.
The remnants of Ian are charging up the East Coast on Saturday after making landfall as a Category 1 hurricane in South Carolina on Friday afternoon.
The monster storm made its first U.S. landfall on Wednesday on Florida's west coast as a powerful Category 4 hurricane, shredding homes with ferocious winds topping 150 mph. Florida's death toll has climbed to at least 81, according to information from local officials.
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5,000 Florida Guardsmen activated and prepping for Hurricane Ian
Florida Gov. Ron DeSantis has activated 5,000 Florida National Guardsmen to armories across the state in preparation for Hurricane Ian, which is forecast to hit the state on Wednesday.
Roughly 2,000 National Guard members from neighboring states such as Tennessee are also being activated to assist, the Florida National Guard said in a statement Tuesday.
"The Florida National Guard is well-equipped, with assets including high-wheeled vehicles, helicopters, boats, generators and more," the statement said.
The U.S. Navy has authorized non-essential personnel in various Florida counties to evacuate.
-ABC News’ Matt Seyler
Landfall forecast for Wednesday afternoon or evening
Hurricane Ian, barreling north toward Florida with 120 mph winds, is now located about 230 miles away from Sarasota.
Ian is expected to make landfall in Florida on Wednesday afternoon or early evening.
Ian's outer bands are already hitting South Florida, bringing a threat of heavy downpours, strong wind gusts, frequent lightning and even tornadoes. A tornado watch is in effect for South Florida until 5 a.m. Wednesday.
-ABC News’ Dan Peck
Walt Disney World, Universal Orlando to close
Walt Disney World and Universal Orlando will close Wednesday and Thursday due to the storm.
Coastal Georgia, South Carolina under tropical storm watches
As Ian moves north over Florida, tropical storm force winds will reach coastal Georgia and South Carolina.
Tropical storm watches have been issued for Savannah and near Charleston.
Georgia Gov. Brian Kemp has issued a state of emergency.
Several Florida airports set to reopen Friday
Tampa International Airport, St. Pete-Clearwater International, Orlando International Airport and Jacksonville International Airport are all set to reopen Friday.
Tampa's first flight is scheduled to arrive at 10:35 a.m. and Orlando will resumer passenger flights after noon. The reopening will be gradual. Orlando already has 445 canceled flights today. Tampa has 152 canceled as of 9:45 a.m.
Jacksonville reopened its Transportation Security Administration checkpoint at 7 a.m. and the airport will be on a reduced operating schedule Friday.
The Federal Aviation Agency closed the Fort Myers airspace to provide a safe environment for search and rescue. It will remain closed Friday.
The Fort Myers Airport will be closed for days, with the FAA saying it won't reopen until at least Oct. 7. United Airlines has canceled all flights out of the airport at least through Monday.
The airports with the most cancelations Friday are Orlando, Tampa and Charlotte, North Carolina.
-ABC News' Sam Sweeney