Republican Sen. Susan Collins condemned the court decision, saying Justices Brett Kavanaugh and Neil Gorsuch's votes did not align with their testimony during their confirmation hearings.

"This decision is inconsistent with what Justices Gorsuch and Kavanaugh said in their testimony and their meetings with me, where they both were insistent on the importance of supporting long-standing precedents that the country has relied upon," Collins said.

Collins voted for Kavanaugh and Gorsuch to serve on the court, for which she faced criticism because of concerns about how their appointments might impact a women's right to choose.

Collins is one of two GOP Senators who is on the records supporting efforts to codify a woman's right to choose.

"The Supreme Court has abandoned a fifty-year precedent at a time that the country is desperate for stability. This ill-considered action will further divide the country at a moment when, more than ever in modern times, we need the Court to show both consistency and restraint," Collins said.

Adding, "Throwing out a precedent overnight that the country has relied upon for half a century is not conservative. It is a sudden and radical jolt to the country that will lead to political chaos, anger, and a further loss of confidence in our government."

Democratic and Republican governors across the U.S. responded to the Supreme Court decision overturning Roe v. Wade.

New York Gov. Kathy Hochul, a Democrat, railed against the ruling but vowed that abortion access is still protected in the state.

"Today, the Supreme Court took away the right of millions of Americans to make decisions about their own bodies," she said in a statement. "This decision is a grave injustice. I want everyone to know that abortion remains safe, accessible, and legal in New York."

In neighboring New Jersey, Democratic Gov. Phil Murphy referred to the decision as "backwards" and "appalling."

"In New Jersey, women will always have full autonomy over their own bodies and the right to make their own medical decisions," he said in a statement.

Michigan Gov, Gretchen Whitmer, also a Democrat, reflected those sentiments,
adding, "I want every Michigander to know that I am more determined than ever to protect access to safe, legal abortion. I'll never stop fighting."

Meanwhile, Republican Gov. Greg Abbott said the Supreme Court made the correct decision in overruling the 1973 decision.

"The Supreme Court correctly overturns Roe v. Wade & reinstates the right of states to protect innocent, unborn children," he said in a statement. "Texas is a pro-life state. We will ALWAYS fight to save every child from the ravages of abortion."

Similarly, Virginia Gov. Glenn Youngkin, also a Republican, said in a statement, "The Supreme Court of the United States has rightfully returned power to the people and their elected representatives in the states. I'm proud to be a pro-life Governor and plan to take every action I can to protect life."

Clinic workers and anti-abortion rights activists shouted at each other and grew more angry outside the Mississippi abortion clinic at the center of the Supreme Court case.

One clinic worker was seen going inside because she was so emotional. The worker was in tears as she tried to hold up a sign that said they were open. Hand-drawn signs were brought out of the clinic because anti-abortion rights activists were turning women away, telling them abortions were now illegal in the state.

Women and couples stopped their cars at the intersection because they were confused as clinic workers hastily tried to tell them they were open, but likely not for long.

A pro-abortion protester outside the clinic told ABC News the decision means they are looking at suffering and death.

"We see what's coming. We know exactly what's going on here. Welcome to the vulture pit. Women without needs will suffer. We've been answering these for years but here we are. America's not ready for what's about to happen with the fall of Rome," one unnamed protestor said.

An anti-abortion protester celebrated the decision, calling it "bittersweet."

"Certainly we're thankful that Roe has been overturned, but our hearts still break over the millions of unborn children ... aborted in this country and it's just gonna be a struggle going to states that still allow abortion and hopefully they'll close this clinic down as quickly as possible and we'll move on and help other places."

-ABC News' Cherise Rudy and Stephanie Ramos

Just The Pill, a nonprofit abortion group, announced a program called Abortion Delivered and vowed to deploy a fleet of mobile clinics to offer "mobile procedural abortions" along the border of states that impose restrictions.

"By operating on state borders, we will reduce travel burdens for patients in states with bans or severe limits," said Dr. Julie Amaon, the medical director of Just The Pill and Abortion Delivered, in a statement.

Abortion law and restrictions vary by state. Some states have trigger laws in place that immediately ban abortion once the federal protection of Roe was overturned.

While state rules can differ, FDA regulations say women can be prescribed medical abortion pills by a certified provider at up to 10 weeks of pregnancy and take them at home.

"We are undaunted. We will bring care to the people who most need it, and we will defy reproductive repression by providing more affordable and accessible care," said Amaon.