California Rep. Adam Schiff said "it's a sober moment for the country," telling Linsey Davis on ABC News Live on Thursday that the dignity of the Oval Office "will be tarnished by the conduct of the former president by his being charged criminally."

"I think you have to be guided by the facts and the law, and you have to set aside the political calendar and do what the law requires," said Schiff, a leading Democrat in the House. "I think that's the obligation of a district attorney, and I think that was done here. How this cuts politically, I really don't know. That, to me, is very secondary."

-ABC News' Imtiyaz Delawala and Anna Katharine Ping

Demonstrators gathered outside Manhattan Criminal Court and near Donald Trump's Mar-a-Lago estate in Florida in the wake of the indictment Thursday evening.

In Manhattan, a giant sign that stated "Trump lies all the time" could be seen unfurled outside Manhattan Criminal Court, where police had erected barricades last week ahead of a possible indictment.

Meanwhile, several supporters gathered near Mar-a-Lago with Trump 2024 flags and signs.

Senate Majority Leader Chuck Schumer urged "Trump’s critics and supporters to let the process proceed peacefully and according to the law" in a statement following the indictment of the former president.

"Mr. Trump is subject to the same laws as every American," Schumer said. "He will be able to avail himself of the legal system and a jury, not politics, to determine his fate according to the facts and the law."

Lawmakers on both sides of the aisle took to Twitter to react to the historic indictment on Thursday evening, laying bare the sharp partisan divide when it comes to Donald Trump.

GOP House and Senate members decried the investigation by the Manhattan district attorney as a political prosecution.

Many Democrats, on the other hand, praised the decision as proof "no one is above the law."

Read more here.

-ABC News' Alexandra Hutzler

Sources familiar with the matter told ABC News the Manhattan district attorney’s office is also investigating a $150,000 payment to Playboy model Karen McDougal, who, like Stormy Daniels, claimed to have had an affair with Donald Trump.

The former president has denied having an affair with either woman and has called the investigation a witch hunt.

McDougal was paid for the rights to her story in August 2016 by American Media, publisher of the National Enquirer, which did not publish it, a practice known as catch and kill.

Michael Cohen, Trump’s former lawyer and fixer, has said he recorded Trump discussing reimbursement to American Media for the payment to McDougal, but the payment was never made.

Trump has not responded to ABC News' request for comment but in a 2018 interview with Fox News, he claimed he wasn't aware of any payment made to AMI to facilitate the alleged hush agreement.