But fellow Oscar winner Mo'Nique took a more measured approach, telling "Entertainment Tonight" she was praying for Bullock -- and her husband.
"I don't wish her nothing but happiness, along with her husband. ... I don't want to see any marriages dissolve or break up," said the comedian. "I hope ya'll make it work."
Perhaps Bullock can check out other famous wives to see whether they chose to stay or go. ABCNews.com rounded up a few of them:
Elin Nordegren and Tiger Woods:
Nordegren has not completely bolted in the face of her husband's sex scandal, which includes allegations of affairs with nearly a dozen women.
Shuter said he is not surprised. "Elin's fortune is really through Tiger," he said. "Her lifestyle is through Tiger."
Woods told ESPN that his wife and mother-in-law have been "very tough" on him following his admission of infidelity. Elin was "hurt, shocked, angry" about his indiscretions," he said. "And she had every right to be."
Divorce seemed certain just three months ago, but then came reports that the couple had reconciled and even spent several nights under the same roof in their Florida compound. By Monday, things had gone downhill again: new reports surfaced that Nordegren was heading back to Sweden and planned to be out of the country when Woods played the Masters.
The jury is still out on this marriage.
Tea Leoni and David Duchovny
In August 2008, Duchovny, the "Californication" star, admitted he had a sex addiction and entered rehab.
The couple, married since 1997 with two children, announced shortly after that they had been separated for several months. Leoni was linked with Billy Bob Thornton, her co-star in the film "Manure."
But by December of that year, Leoni and Duchovny had quietly decided to make another go of their marriage. They stepped back from their Hollywood lives, relocating from Los Angeles to New York, and took a summer caravan trip across the states with their children. At the Toronto film festival last September, Duchovny said, "Everything is great. Tea is a great partner, wife, and mother."
Last December, the couple made their first red carpet appearance together at the UNICEF snowflake ball. It was a long road back to reconciliation, but Duchovny and Leoni proved it's possible.
Halle Berry and Eric Benet
Berry initially stood by her man following tabloid reports that he had several affairs. He sought therapy for sex addiction while she worked hard to make her second marriage work.
But after Benet had another relapse, Berry finally called it quits, filing for divorce just months after winning her best actress Oscar.
The following month, Berry made headlines again when she said on "Oprah" that she would "never, never" marry again. Berry has a daughter Nahla with model boyfriend Gabriel Aubry.
Vanessa and Kobe Bryant
After he was accused of raping a 19-year-old woman in the summer of 2003, NBA superstar Kobe Bryant admitted that he committed adultery with the woman but insisted the sex was consensual.
At a press conference, in which his wife Vanessa famously sat beside him, he said, "I'm innocent. I sit here in front of you guys furious at myself, disgusted at myself for making a mistake of adultery."
Bryant was found not guilty and his wife stayed. Her loyalty was rewarded with an eight-carat diamond ring reportedly worth $4 million.
Christie Brinkley and Peter Cook