And these contraindicated drugs might even work in hemodialysis patients at the right doses, it's just that no one has ever looked at this, explained Dr. William O'Neill, executive dean for clinical affairs at the University of Miami Miller School of Medicine.
"Poor kidney function almost always disqualifies patients from clinical trials," he explained. "Do the drugs get filtered out [of the bloodstream by the kidneys]? Basically nobody knows because nobody has done the trials. There is just an absolute glaring lack of information about how to use these drugs in these patients. This study does suggest a fundamental lack of understanding of these drugs among a significant minority of physicians."
The American Heart Association has more on percutaneous coronary intervention.
SOURCES: Thomas T. Tsai, M.D., director, interventional cardiology, Denver VA Medical Center, and assistant professor, cardiology, University of Colorado Denver School of Medicine; Gregory Dehmer, M.D., professor, internal medicine, Texas A&M Health Science Center College of Medicine, and director, cardiology division, Scott & White, Temple, Texas; William O'Neill, M.D., executive dean, clinical affairs, University of Miami Miller School of Medicine; Dec. 9, 2009, Journal of the American Medical Association