When she was a girl, Jane Fraser recalls her father, Malcolm, asking her to give their name when they checked into a hotel.
"It's all over my family, and a lot of us stuttered as children but got therapy early on," said Jane Fraser, noting that she received speech therapy because of the suspicion at the time that stuttering runs in families. For her, the therapy may have spared her from the condition.
"None of my generation or their children or their grandchildren have that problem," she said.
On Wednesday, researchers confirmed what some have long suspected by finding genes that account for some cases of stuttering, a condition that affects about 3 million Americans.
It is a development that Fraser and others believe will allow better recognition of the condition and more early intervention and be the first step toward resolving an ailment that affects many worldwide.
"I think one of the most exciting things [about the finding] is that people who stutter have to spend their lives telling people it is not psychological, it is not emotional," said Fraser, who is now president of the Stuttering Foundation of America, an organization founded by her father.
This study, she said, "takes that burden off of people of having to explain what it is.
"Every day, we hear from hundreds of parents who call us, and their first question is, 'Did I cause my child's stuttering?'" she said. "Knowing there is a biological base at least relieves that person of guilt."
The study, which appears in the most recent issue of the New England Journal of Medicine, found three gene variants on chromosome 12 in Pakistani populations that appear to correspond with stuttering, as they appeared in afflicted individuals but not in others.
While the genes were initially located within a Pakistani population, the same gene was later found in people of European ancestry who stuttered -- a finding that has made researchers optimistic that their findings will apply to a larger population.
"While people have known that genetic factors in general seem to be responsible in some cases of stuttering, we've now found some of those factors," said lead study author Dennis Drayna, a geneticist at the National Institute on Deafness and Other Communication Disorders.
"This study will allow our greater society to no longer stigmatize stuttering as simply a disorder where one 'needs to slow down' or that one 'needs to relax,'" said Dr. Gerald A. Maguire, a psychiatrist specializing in stuttering treatment at the University of California, Irvine School of Medicine.
"In a sense, it's like a mythbuster," said Fraser.
Despite the promise seen in from the new study, it remains unclear how many will be helped without further research.
"The results from this study could advance our understanding of how genetics contribute to the etiology of stuttering," said Joseph Donaher, a specialist in fluency disorders at the Center for Childhood Communication of the Children's Hospital of Philadelphia.