Many Livers 'Too Fat' For Transplant

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SAN DIEGO -- Increases in factors associated with fatty liver disease may be leading clinicians to discard more donated organs, researcher found.

In an analysis of data from the United Organ Sharing Network (UNOS), age, obesity, diabetes, and hypertension were associated with an increased risk of a liver being discarded, Dr. Eric Orman of the University of North Carolina at Chapel Hill and colleagues reported during a press briefing at Digestive Disease Week here.

"We're actually throwing out livers that in the past may have been able to be used ... [because] of all these factors associated with fatty liver disease," Orman explained.

Read this story on www.medpagetoday.com.

Orman said that over the past few years, there's been a decline in the number of liver transplants done, but that drop isn't explained by flat donation rates alone.

"Although donation rates have decreased overall, they haven't decreased to the same extent as the decline in the number of livers transplanted," he said, adding that one explanation may be an increase in discard rates due to poor quality of organs.

So he and colleagues conducted a retrospective study of data from UNOS between 1994 and 2010 totaling 93,232 organ donors. Living donors, split livers, and donors with a body mass index of less than 14 or more than 50 kg/m were excluded.

Among the nearly 94,000 donors, 75 percent of livers were transplanted and a quarter of livers were not used.

They found that the number of discarded organs was stable until 2003 (with a total of 1,058 organs discarded in that last year), and then rose to 1,828 by 2010.

In a bivariate analysis, they found that discarded livers more often came from donors who were older (median 49 versus 43 years), obese (35 percent verses 22 percent of non-obese donors), diabetic (35 percent versus 24 percent of nondiabetics), and hypertensive (31 percent versus 22 percent of normotensive patients).

Discard rates were also higher in donation after cardiac death, which is different from standard procurement. In the latter, a patient is declared brain dead but kept on a ventilator to keep the organs perfused (65 percent versus 22 percent). In donation after cardiac death, perfusion of blood to the organs is disrupted.

They estimated that in 2010, 44 percent of discards were due to increased age, 9 percent to obesity, 5 percent to diabetes, and 5 percent to hypertension. These proportions were stable over time, they said.

On the other hand, the proportion of livers discarded due to donation after cardiac death rose from 0.2 percent in 2000 to 26 percent in 2010, suggesting an increasing reluctance to use these grafts, they reported.

Orman said that, overall, the findings are important "because if these trends continue, we're going to see further declines in liver transplant."

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