Since starting lonafarnib five years ago, Megan Nighbor has grown a little, her translucent skin has thickened and her bones are stronger, according to her parents.
"We knew we were in good hands from the day we started," said Nighbor's dad, Steve Nighbor. "But to see these changes now and to finally have some hard numbers, you just know that everything Megan's gone through was worth it."
Now in sixth grade, Nighbor is nicknamed "Hollywood" because of her blond wig and big sunglasses.
"She was in a shell when she was younger but she's definitely popped out," said her mom, Sandy Nighbor. "She's not shy anymore."
The Nighbors, who live in the small town of Dalton, Wisc., helped raise $100,000 for the Progeria Research Foundation to fund the $2 million trial.
"Everyone wanted to help," said Sandy Nighbor, recalling a bake sale where her pies sold for $700. "Now we have something we can actually show them and say, 'Look at what you did for us.'"
The Nighbors hope the exciting results fuel even faster progress in progeria research.
"People need to understand we don't have the luxury of time," said Sandy Nighbor. "We need to keep going."