Lab-Grown 'Custom' Organs May Be Future of Medicine

June 25, 2012— -- What if dying patients waiting for an organ transplant could receive a custom, lab-grown replacement rather than waiting for a donor organ?

To some, this may sound like science fiction -- and in many ways, it still is. But the advances in the field of regenerative medicine that made headlines last week suggest such lab-grown organs may become reality in the future.

One of these advances was Swedish scientists' creation of a custom vein that has carried blood from a little girl's intestines to her liver for a year and counting. In another, a group in Japan successfully implanted lab-grown livers made from human cells into mice -- organs that metabolized drugs the way they would in a human.

And these developments may be just the tip of the iceberg. From skin to blood vessels to solid organs, work is underway to offer more options for patients with faulty or damaged body parts.

Dr. Anthony Atala, director of the Wake Forest Institute for Regenerative Medicine in Winston-Salem, N.C., was part of the first group in the world to successfully implant a lab-grown organ into the human body. Atala's interest in the field began when he was training to become a urologist and saw numerous children who had undergone bladder replacement surgery. Many of them were experiencing leaks, and some even suffered ruptures of their new bladders.

"That's when I really thought, 'Why not try to grow these children new bladders from their own cells?'" Atala said.

Atala collected a small number of cells -- about the size of half a postage stamp -- from the original, inadequate bladders of children with spinal cord birth defects. Each child's own cells were multiplied in the lab and then placed on a biodegradable scaffolding. In seven weeks, the cells had grown to fill in the scaffold, creating a new bladder. The procedure was first performed in 1998, and by 2006 they had seen long-term success of the organs.

"I still hear from some of them occasionally," Atala said. "They are still walking around with their engineered bladders, and they are happy with them."

Since this first foray into growing organs, Atala has been one of the many doctors on the forefront of what some say could one day be a new paradigm in medicine -- growing spare parts from a patient's own cells.

Atala currently heads up more than 300 researchers in the Wake Forest University lab who are working on growing more than 30 different organs and body tissues.

In one trial for the U.S. Armed Forces, his team is collecting healthy skin cells from injured soldiers, processing them, and then spraying them onto battle wounds as a tailored treatment for healing. For deeper wounds, they are in the process of developing an ink jet printer that scans a wound and creates a custom map of the defect.

"After the scan, the printer can go back and print multiple layers of cells right over the wound," Atala said.

The idea of using a patient's own cells rather than relying on those of a donor is important because it eliminates the need to find a "match." For any transplant procedure there is a concern that tissues from a donor will be rejected by a recipient's body.

Even though doctors carefully analyze specimens under a microscope to find the most compatible individuals, and even despite the powerful drugs used to prevent the recipient's immune system from attacking the new body part, the risk of rejection still causes doctors to hold their breath in the days following a transplant.