Amanda Knox's family told ABC News they are disappointed, but not surprised, that an Italian court refused to let her out of prison while an investigation continues into the murder of her roommate.
The 20-year-old college student from Seattle has been held in an Italian jail since Nov. 6, when she was arrested just days after her British roommate, Meredith Kercher, was found dead in their Perugia apartment with a stab wound to the neck.
Knox is being jailed along with her ex-boyfriend, Italian Raffaele Sollecito, 24, and Rudy Hermann Guede, 21, of the Ivory Coast.
Lawyers for all three suspects appealed Tuesday for their release, but the Court of Cassation rejected the requests.
"We are disappointed in the court's decision, but not surprised by it as the court has seldom overturned the rulings of the lower courts," Knox's family said in a statement to ABC News.
"We continue to believe in Amanda's innocence and believe that she should be released," the family said.
None of the suspects has been charged in the case, but prosecutors have told court hearings they believe that more than one person was involved in Kercher's apparent murder.
Guede, who fled to Germany after Kercher's body was found, initially told investigators that he had been with Kercher on the night she died. He said he left the room briefly and when he returned he scuffled with a knife-wielding man whose face was hidden by a hood. He also told a court that he did not see Sollecito or Knox at the apartment that night.
Last week Guede told investigators that he recognized the guy in the hood to be Sollecito and that he clearly heard Knox's voice in the doorway, according to Italian press reports.
Guede also said that Knox and Kercher hated each other and that Kercher had accused Knox of taking money from her dresser, the reports said.
Knox has denied any involvement in Kercher's death and said she was at Sollecito's apartment that night.
Knox's parents have called Guede's most recent version of events "impossible to believe."