“It was painful,” Giuliana told People magazine. “We were so optimistic with this last embryo. We thought, ‘This is definitely going to work.'"
Rancic, 40, and her husband welcomed their son Duke more than two years ago, and through social media, the couple has shown what a blessing their son is to them.
With no more embyos, the couple is looking towards adoption and giving Duke a sibling.
“I think adoption is a beautiful gift you’re giving each other," she said. "And it’s funny, I’m even more open to [adoption] than I was before. Because I think to myself, ‘I love Duke so much, if I couldn’t take care of him, I hope there would be someone else who would love him.’ ”
A byproduct of the cancer-suppressing medication is also a slim figure. The "Fashion Police" co-host also spoke to the magazine to dispel any ridiculous theories that were being spread on social media.
Rancic has been taking the medication since 2012, which has had an effect on her metabolism, making it difficult to gain weight.
"I started noticing that I was eating a lot, but not gaining weight at all. I was concerned," she explained. "I eat more than any of my friends. I eat a very robust, healthy, balanced diet and dessert almost every night. I'm not hiding from anything."
The TV personality said the attention has been hard to hear. "It's really hurtful," Rancic added. "I'm sorry that some people think I'm disgustingly skinny, as they put it, but there's nothing I can do. I'm lucky that I even have the type of cancer that reacts to the medicine."
Rancic said she would even prefer to put on weight, if she could. "I look in the mirror and it's hard for me," she admitted. "I am really thin. I want to look fit and beautiful and sexy, and I can't."
The mother of one said now she tries to focus on the positives. "I refuse to be broken. I have so many beautiful things in my life," she added.
Rancic is set to release a memoir, "Going Off Script," on April 7.