The game's simple: You gotta be trapped with five people in a house for the duration of the COVID-19 pandemic. Choose wisely (or not wisely, depending on your taste and drama tolerance).
The meme appears to have started with groupings of celebrities:
House No. 4 looks to be the wisest choice there, though House No. 3 does seem as though it could veer sideways in an enjoyable way.
Note: It is already possible to be stuck inside with James Joyce for months on end.