Speaking to The New Yorker after her arrest, McGowan said, "I will clearly plead not guilty."
McGowan, 44, who will be arraigned Thursday, and her lawyer are arguing that drugs found in her wallet, which was left behind on a flight to Washington Dulles International Airport in January, could have been planted.
Her lawyer did not respond immediately to ABC News' request for comment.
McGowan faces a felony charge for possession of a controlled substance.
On Tuesday night she turned herself in to the Loudoun County Sheriff's Office in Virginia and was released on a $5,000 secured bond.
In a statement last month, the Metropolitan Washington Airports Authority Police Department said, "The felony charge stems from a police investigation of personal belongings that tested positive for narcotics and were left behind on United flight 653 arriving at Washington Dulles International Airport on Jan. 20, 2017."
According to the statement, the department obtained an arrest warrant for McGowan on Feb. 1 and attempted to contact her so that she could appear in court to respond to the charge. The warrant was later entered into a national law enforcement database, the statement said.
Through his rep, Weinstein has "unequivocally denied" any "allegations of nonconsensual sex."
Last month, McGowan revealed on Twitter that she was facing a warrant for her arrest.
"Are they trying to silence me?" she tweeted on Oct. 30, calling the arrest a "load of horses---."
McGowan told The New Yorker that during the flight she never removed her wallet from her backpack, which she left on the seat while she went to the lavatory. It was while waiting for a car service outside the airport that she realized her wallet was gone, she said.