Hosting for the 16th year in a row, Seacrest will be joined in New York City by co-hosts Lucy Hale and Billy Porter. During the broadcast, Seacrest will speak with President-elect Joe Biden and future first lady Jill Biden.
Singer Ciara will return for the fourth year as the West Coast host, and Freedia will be at the helm of the the fifth-annual celebration from New Orleans.
"In a year marked with many challenges, we are honored that President-Elect Joe Biden and Dr. Biden will join America's most-watched tradition -- 'Dick Clark's New Year's Rockin' Eve' -- to share an inspiring message as we come together to close out 2020 and look ahead with hope to 2021," said Amy Thurlow, president of Dick Clark Productions, and Craig Erwich, president of Hulu Originals and ABC Entertainment, in a joint statement.
Jennifer Lopez will be this year's headline performer, taking the stage right before the iconic ball drops in Times Square at midnight, along with Porter, country star Jimmie Allen, Machine Gun Kelly and Cyndi Lauper. Lauper and Porter, who worked together on the Broadway show "Kinky Boots," will also sing a duet during the broadcast.
Meanwhile, Brandy, Doja Cat, Ella Mai, En Vogue, Julia Michaels and JP Saxe, Lewis Capaldi, Maluma, Megan Thee Stallion, Miley Cyrus, Nelly, and Saweetie will perform in Los Angeles. PJ Morton will perform "Auld Lang Syne" from New Orleans.
Singer Jessie James Decker returns as Powerball correspondent for the second year and will reveal the "Powerball First Millionaire of the Year" just after midnight.
The fun gets underway at 8 p.m. ET/7 p.m. CT, live on ABC.