Dr. Martin Salia is expected to arrive in the United States on Saturday and will receive treatment at Nebraska Medical Center, the official told ABC News.
It is unclear how he contracted Ebola, but the official said he was in Sierra Leone at the time.
A hospital spokesman would only say that the would soon be evaluated for possible treatment. He would not give any other details.
In a statement, Jen Psaki, a spokeswoman for the State Department, said they were working "in consultation with the Centers for Disease Control and Prevention" and were "in touch with the family of a U.S. legal permanent resident working in Sierra Leone who has contracted Ebola.
"His wife, who resides in Maryland, has asked the State Department to investigate whether he is well enough to be transported back to the University of Nebraska Medical Center for treatment," the statement added.
This comes two days after Dr. Craig Spencer, who contracted Ebola treating patients in West Africa, was discharged from a New York City hospital Ebola-free.
Spencer, 33, who treated Ebola patients in Guinea for Doctors Without Borders, spent 20 days in isolation at Bellevue Hospital in Manhattan after testing positive for Ebola there on Oct. 23.
More than 5,000 people have died in the Ebola outbreak that is ravaging parts of West Africa, the World Health Organization reported on Wednesday.
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