One official said the jihadist, Mohammed Emwazi, was thought to be hit as he left a building in Raqqa, Syria, and entered a vehicle. The official called it a "flawless" and “clean hit” with no collateral damage and that Emwazi basically "evaporated."
Diane Foley, the mother of Emwazi's first victim James Foley, told ABC News Emwazi's potential death would be "really a small solace to us."
"This huge effort to go after the this deranged man filled with hate when they can't make half that effort to save the hostages while these young Americans were still alive," said Foley, who has been critical of the U.S. government's hostage policy.
British Prime Minister David Cameron spoke at a press conference early Friday, "We cannot yet be certain if the strike was successful. I've always said we would do whatever it takes to track him down, we've been working with the United States around the clock."
He added, "I want to thank the United States, the United Kingdom has no better ally."
Richard Clarke, a former counter-terrorism advisor to the White House and current ABC News consultant, said, "Since ISIS has used propaganda and its 'winner' image to lure new adherents, when its propaganda figure is killed that makes it look more like a loser, more like the tide may be turning against it."
After Emwazi was unmasked and identified in media reports in February, he ceased to appear in videos for ISIS.