Israel-Gaza-Lebanon live updates: Missile from Yemen targeting Israel intercepted

Iran "will not remain indifferent in case of a full-scale war in Lebanon," Iranian Foreign Minister Abbas Araghchi told reporters Wednesday on the sidelines of the United Nations General Assembly in New York City.

Araghchi also warned that Israel's "crimes will not go unpunished," and said the Middle East region "risks full-scale conflict" if the U.N. Security Council does not "act now to halt Israel's war and enforce an immediate ceasefire."

"The path to de-escalation is clear," Araghchi said. "Israel must immediately stop its attacks on Gaza and Lebanon. Without a ceasefire in Gaza, there will be no guarantee of peace in the region."

"The Security Council must act now to halt Israel's war and enforce an immediate ceasefire, and by that, to save innocent lives. If not, the region risks full-scale conflict and history will hold Israel's enablers, especially the United States, responsible."

"Iran will not remain indifferent in case of a full-scale war in Lebanon," the diplomat added. "We stand with the people of Lebanon with all means."

-ABC News' Ellie Kaufman

On Wednesday, at least 81 people were killed and 403 were wounded in Israeli strikes on Lebanon, according to the Lebanese Ministry of Public Health.

In total, more than 650 people -- including at least 50 children -- have been killed and over 1,700 others injured since Monday, according to the ministry.

The U.S. is currently "in active discussions" with Israel and other countries to try to secure a cease-fire between Israel and Hezbollah, according to a U.S. official.

The Biden administration has floated at least one draft proposal aimed at temporarily halting the conflict, but Israel has signaled it intends to move forward with battle plans aimed at ending months of tit-for-tat exchanges with Hezbollah across its northern border by decimating the militant group, two officials told ABC News.

Negotiations are still ongoing, but at this hour officials said they are growing increasingly resigned to full-blown warfare on a second front in the Middle East.

The U.S. also has little leverage over Hezbollah, so it’s unclear whether the group would abide by any such agreement to pause the fighting, officials said.

The administration could potentially rely on partners with direct ties to Hezbollah to contain the group, but all of its efforts to halt its attacks on Israel over the last year have been unsuccessful, officials said.

The U.S. is still pursuing "concrete options" for de-escalation, and Israel’s ambassador to the United Nations said on Tuesday that Israeli leadership remained "open-minded," officials said.

The Biden administration is also still fervently focused on keeping Iran -- a chief military and financial supporter of Hezbollah -- on the sidelines through indirect diplomacy. Multiple conversations between countries that communicate directly with Iran are taking place on the sidelines of United Nations General Assembly, officials said.

-ABC News' Shannon K. Kingston and Michelle Stoddart

Israel Prime Minister Benjamin Netanyahu said the operation in Lebanon will continue, despite international calls for a diplomatic resolution to Israel's conflict with Hezbollah.

"I cannot detail everything we are doing, but I can tell you one thing, we are determined to return our residents in the north safely to their homes. We are inflicting blows on Hezbollah that [the group] did not imagine. We do it with power, we do it with guile. I promise you one thing -- we will not rest until they come home," Netanyahu said.