Democratic leader Hakeem Jeffries released a statement Wednesday wishing McCarthy well after he voted to remove him from speakership, and encouraged Democrats to do the same.

"Since January, Kevin and I have had a respectful, communicative and forward-looking relationship," Jeffries said. "On many occasions, we strongly disagreed with each other. However, we agreed to disagree without being personally disagreeable in order to find common ground whenever possible."

Jeffries commended McCarthy's initiatives on economic competition with China and artificial intelligence, stating that work should continue.

"I wish Speaker McCarthy, his family and dedicated staff Godspeed as he begins the next chapter in his public service and professional journey," Jeffries said.

-ABC's Lauren Peller

Senate Minority Leader Mitch McConnell urged House Republicans to do away with the motion to vacate, contending it "makes the Speakers' job impossible."

Many Republicans ABC News talked to on the House side agree with him. For some, it's a major factor in who they will support for speaker.

Rep. David Joyce, R-Ohio, said he'll back "the first one who starts talking about the fact we're not going to have a stupid rule anymore that allows one person to take a speaker out. That's ridiculous."

"It absolutely has to change," he added, noting if it doesn't, the GOP could find itself right back in this same position.

Even Colorado Rep. Ken Buck, one of the eight Republicans who voted to oust McCarthy, says he's OK with changing the rule from a one-vote threshold back to a five-vote threshold to vacate.

"I'm fine with a five vote. If you can't get five Republicans to say the speaker should be vacated, then live with it. But I don't think the rules are the problem. I think the credibility of the former speaker was the real problem," he said.

-ABC's Mary Bruce

In remarks about the speakership showdown, Biden said there is a "lot of work" to get done as Congress faces a Nov. 17 deadline to come to a funding deal or once again risk a shutdown.

"We cannot and should not again be faced with an 11th-hour decision, brinksmanship that threatens to shut down the government," Biden said.

He also expressed concern on the current state of future aid for Ukraine, admitting he's worried it may not happen.

"It does worry me," he said. "But I know there are a majority of members of the House and Senate in both parties who have said that they support funding Ukraine."

At least one lawmaker vying for speaker has long been opposed to additional Ukraine aid.

"I'm against that," Rep. Jim Jordan told reporters on Wednesday. "What I understand is at some point we're going to have to deal with this appropriation process in the right way and we're going to try to do that in the next -- what are we down to? Forty-one days. The most pressing issue on the mind of Americans is not Ukraine, it is the border situation."

-ABC's Molly Nagle, Justin Gomez and Mary Bruce

Scalise made his case for why he should be the next House speaker in a letter to colleagues on Wednesday.

In it, he called the Republican conference a "family" as he recounted the support he received when he was shot during congressional baseball practice in 2017 and suffered life-threatening injuries.

"God already gave me another chance at life," he wrote. "I believe we were all put here for a purpose. This next chapter won't be easy, but I know what it takes to fight and I am prepared for the battles that lie ahead."

Steve Scalise - Dear Colleague - October 4 2023 by ABC News Politics on Scribd

Now-former Speaker McCarthy addressed reporters from Capitol Hill on Tuesday night where he looked back at his years in Republican leadership, touted his record -- and struck an optimistic if ambiguous note about his future.

"I believe I can continue to fight," McCarthy said, while noting that he will not run again for speaker after he lost a historic vote on the motion to vacate earlier in the day.

"My goals have not changed. My ability to fight is just in a different form," he said, later adding, "I'll never give up on the American people. That doesn't mean I have to be speaker."

McCarthy also swiped at the conservative rebels who ousted him from his role -- stressing that they were just 4% of the GOP conference -- and claimed that Gaetz was acting out of a personal sense of grievance in pushing him out, which Gaetz denies.

Despite the defeat he suffered from within his own party, McCarthy sounded largely sanguine about his political career.

He contended that the Democratic minority deciding to vote against him had made a "political decision" that undercut the ability of the House to govern.

"My fear is the institution fell today," he said.

Still, in largely valedictory remarks, he pointed back to work to cut government spending, expand his party's base and increase their majority in Congress, including by electing more women and minorities.

"I feel fortunate to have served the American people," he insisted. "I leave the speakership with a sense of pride, accomplishment and, yes, optimism."

-ABC News' Adam Carlson