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In one sketch, McCarthy's easily agitated Spicer holds one of his infamous press briefings dressed as the Easter Bunny. The sketch pokes fun at Spicer's controversial comments this past week comparing Syrian dictator Bashar al-Assad with Adolf Hitler, which left many observers calling for his resignation.
"Everybody shut up so I can apologize," McCarthy's Spicer says. "You all got your wish this week, didn't you? Spicey finally made a mistake."
VIDEO: "EASTER MESSAGE FROM SEAN SPICER"
The show's cold open featured Baldwin's Trump speaking with Vice President Mike Pence, played by "SNL" cast member Beck Bennett, in the Oval Office.
The sketch poked fun at the president's frequent visits to Mar-a-Lago, his achievements so far, in-fighting in the White House, and North Korean leader Kim Jong-un.
VIDEO: COLD OPEN
"So many memories in this room," Baldwin's Trump says during the cold open. "This is where I met with the Chinese president."
Bennett's Pence corrects the president, saying, "That was at Mar-a-Lago, sir."
Baldwin's Trump continues, "This was where I ordered the Syrian strike."
Yet again, Bennett's Pence corrects the president: "That was also at Mar-a-Lago, sir."
The cold open also mocks the president's knowledge of foreign affairs.
Says Baldwin's Trump: "Remember when I refused to shake the hand of that little German boy?"
"You mean, Angela Merkel?" says Bennett's Pence.
"Whatever his name is," responds the commander in chief.
As the show has in the past, the cold open portrayed White House chief strategist Steve Bannon as the Grim Reaper.