In her "Good Morning America" appearance on Thursday, Manigault referred to herself multiple times as "the only African-American woman in this White House" and later said "there is a lack of diversity that I will acknowledge" among Trump's senior staff.
White House press secretary Sarah Sanders was asked in Thursday's daily briefing if she knew how many senior staffers currently in the White House are African-American.
"I don't have a number directly in front of me, specifically African-American," Sanders said. "But I can say, again, we have a very diverse team at the White House, certainly a very diverse team in the press office and something we strive for every day is to add and grow to be more diverse and be more representative of the country at large."
Sanders added that "a number of people" will be involved in the process of replacing Manigault Newman in her role as director of outreach to the African American community.
The White House has not responded to follow up questions from ABC News asking for clarity on the number of African-American senior staffers in the White House.
According to Robert C. Smith, author and professor of political science at San Francisco State University, that lack of diversity in the White House could have a broader trickle-down effect on the makeup of the rest of the administration. Smith provided ABC News with research he published in 2016 showing the percentage of African-American political appointees dating back to the Kennedy-Johnson administrations.
(*treated as one administration for purposes of data collection)
Smith said he planned to begin compiling similar data for the Trump administration later next year, which he expects to be "akin to the Nixon record."
"Both symbolically and in terms of public policy this is a significant departure from the recent past," Smith said. "This disadvantages the administration in policy making."
Max Stier, the chairman of the nonpartisan Partnership for Public Service which advocates for greater government accountability, pointed to public data from the Office of Personnel Management's "FedScope" showing the divide between the number of minorities and non-minorities appointed to the administration thus far.
"It's predominantly white and it's predominantly male," Stier said. "There are no requirements, so it's not in terms of if this is a legal issue of the choices that are being made, but I think there are legitimate questions that can be asked about whether the makeup of the leadership of any administration reflects the people that it's representing, the broader country."
But Stier also noted that the shortfall is not entirely unique to the Trump team.
"Obama had a much more diverse workforce in the political ranks than President Bush did," Stier said. "President Trump so far looks more similar to President Bush's."
"I don't think she was given much latitude to go out and try and build relationships with the African American community," Smith said. "It's caused great skepticism about the administration from African Americans and about her as well."
Trump's highly controversial handling of the Charlottesville protests and his repeated attacks against his predecessor Barack Obama and his legacy could additionally contribute to hesitation among prominent African Americans to want to join the administration, Smith said.
"Not just a black face, but recruiting a black person of substantive knowledge and responsibility," Smith said. "Even among some black conservatives you've probably got some reluctance to serve in a Trump administration."
"I have seen things that have made me uncomfortable, that have upset me, that have affected me deeply and emotionally, that has affected my community and my people," Manigault said.