Rose has a strained left hamstring, while Gasol is suffering from a strained left calf.
"[They're] just not ready," Bulls coach Tom Thibodeau said before Thursday's shootaround.
This will be the third straight game Rose has missed after initially injuring the hamstring in last Thursday's win over the Toronto Raptors, and the seventh game total. He missed four games earlier this season because of sprained ankles. Gasol, who along with swingman Jimmy Butler has now missed two straight games because the calf injury, is hopeful he will be back on the floor soon.
"I didn't feel a pop," Gasol said of the injury. "It just started bothering me. It started being sore. I was hoping I got hit but I couldn't recall getting hit. So then you had to figure it was a muscle strain and strains usually take their time to heal and scar. So I'm just trying to let it heal."
The Bulls' next game is Friday night against the Portland Trail Blazers.