Coming up … Three Big Exclusives: David Axelrod, Sen. Mitch McConnell and Queen Rania of Jordan

Plus, all the week's politics on the roundtable.

September 23, 2010— -- As President Obama tries to stop a Republican wave in November, can he shore up his base? The president's top political adviser, David Axelrod talks to "This Week" anchor Christiane Amanpour about the fall elections and whether Democrats can hold the House.

And revelations in Bob Woodward's new book about the president's conduct of the war in Afghanistan raises questions about what role politics played in crafting the war policy. David Axelrod in a "This Week" exclusive.

And with the GOP poised to make gains in Congress, Senate Republican Leader Mitch McConnell comes to "This Week" for an exclusive interview. How does he size up his party's chances to take control of the Senate? Will the Tea Party's success undermine his chance of becoming majority leader? And, after enchanting primary voters in Delaware, will Sarah Palin-backed Senate Republican candidate Christine O'Donnell be able to pull off another upset in the fall? Senate Minority Leader Mitch McConnell, only on "This Week."

Then, Christiane sits down with Queen Rania of Jordan in another exclusive interview. With the U.N. General Assembly meeting this week to renew its pledge for the Millennium Development Goals, Christiane talks to Queen Rania about her work on global poverty, women's health and education. They'll also discuss the Middle East peace talks and the battle against extremism.

Plus our roundtable with George Will, Democratic political strategist Donna Brazile, former Bush political strategist Matthew Dowd and Ron Brownstein of the National Journal who has a comprehensive look at the Republicans running for Senate and why he believes they are the most ideologically cohesive group of candidates that a party has ever fielded.

Axelrod, McConnell, Queen Rania and all the week's politics, Sunday on "This Week with Christiane Amanpour."

You won't want to miss it.