The pre-game attire of Newton, one of the league's best-known black players, was an apparent acknowledgment of the concerns of demonstrators who have held daily protests since the police shooting death of an African-American man, Keith Lamont Scott, early last week.
The press release said "a variety of intelligence sources indicate that protests and acts of disruption will continue in Center City, Charlotte. Considering there will be large open crowds with public access, there is potential that harm could take place if a so motivated individual or group had the desire to do so," the release says. "In order to provide a safe and secure environment, we will need to expend significant public safety resources during this event."
But early reports indicated large but peaceful demonstrations near the stadium, with the crowd surrounded and contained by police.
Newton, speaking to the press Wednesday, called the fatal shooting of Scott "embarrassing" and said that it touched on a "state of oppression in our community."
Peaceful demonstrations and violent clashes have shaken the city of Charlotte every day since Scott was killed by a black police officer on Tuesday.
The shooting took place in an apartment complex parking lot not far from the stadium, and protests moved within a few blocks of that area starting on Wednesday.
The scene grew especially tense Wednesday night when police clad in riot gear fired tear gas and rubber bullets at demonstrators. Some people in the crowds threw bottles and rocks at officers and passing cars, blocked an interstate highway, surrounded and jumped on vehicles, looted businesses and stormed the entrance of a Hyatt hotel, injuring two of its employees.
A protester was shot by another civilian, and later died.
The protests have since continued but have been largely peaceful, including on Saturday after video of Scott's shooting was released by police.
Prior to the events of the past week, Newton has recently been a target of criticism by some in the black community for comments suggesting he wanted to distance himself from racial issues.
GOP pollster Frank Luntz, who has worked as a public relations adviser with the Panthers in the past, has worked to help Newton forge a post-racial identity, according to an article in Sports Illustrated.
ABC News' Mariam Khan contributed to this report.