The man was en route home via Houston when he stood up and felt light-headed and dizzy.
"He was really pale in color and he was sweating profusely," said Van. "I started noticing that he's not breathing, he does not have a pulse. I immediately started CPR ."
Van and George hooked the man up to an IV and an auto-external defibrillator provided by the flight crew.
The plane was diverted to Phoenix, where the man was taken to a hospital. He was alert and talking, said the paramedics.
"It doesn't matter if you're 30,000 feet up in the air or on the side of a freeway or in someone's home, our skill set allows us to help people in need when they need it," said George.
"This is not a career. It's a way of life," said Van. "Wherever you go, you will have to respond."