The shelter said it evacuated 62 dogs "out of harm's way" and planned to evacuate 25 kittens and four bunnies before the week’s end, according to its website. It had more than 550 animals in its care as of Thursday.
"We are standing by and ready to support Tri-County emergency pet shelters for the public," the Animal Society said. "We expect most of the evacuations and other responses will increase with flooding over the next week or so, at which time, CAS will serve as a regional staging area for supplies, etc."
It said residents should put their safety first, but "let's not forget our animals as this dangerous storm approaches."
Other shelters in the storm path made appeals to the public this week, asking residents to open their homes to pets in need ahead of the hurricane.
Saving Grace, an animal shelter in Wake Forest, North Carolina, said people in its community came together to help house more than 120 dogs who were still "waiting for their forever homes."
"We are grateful for those individuals in our community who stepped up yesterday to open their homes to 124 Saving Grace dogs," the shelter said Thursday. "All these dogs came to us in need, some from evacuated shelters this week and some have been with us prior to 'Florence' waiting for their forever homes.
"We may have a small shelter but our volunteers and the difference they make in the lives of many is huge," it added.